妊娠期糖尿病患者氧化应激水平变化及临床意义
发布时间：2021-06-15 23:50
目的:研究GDM孕妇与正常孕妇血清MDA、SOD及GSH水平变化,探索它们与GDM之间的相互关系,追踪各组妊娠结局研究其临床意义。方法:选取175例孕妇为研究对象,分为GDM组（93例）和对照组（82例）。采用微量法测定血清丙二醛（MDA）、谷胱甘肽（GSH）及超氧化物歧化酶（SOD）水平,并对妊娠结局进行相关性分析。结果:（1） GDM组年龄、孕前体重、BMI值均高于对照组,GSH和SOD水平均低于对照组,MDA水平高于对照组,差异有统计学意义（P<0.05）;（2） GDM组MDA水平与孕前体重呈负相关（r=-0.3547,P<0.05）,SOD水平与新生儿出生体重呈正相关（r=0.3292,P<0.05）,SOD值与早产之间有密切联系（足月产12.68±0.85 vs.早产8.08±1.18, P <0.05）,GSH、SOD水平与孕前体重之间,MDA、GSH水平与新生儿出生体重之间,MDA、GSH水平与早产之间均无明显相关性（P>0.05）,MDA、GSH和SOD水平与剖宫产及胎膜早破均无明显相关性（P>0.05）。结论:GDM存在明显的氧化...
【文章来源】：现代生物医学进展. 2019,19(01)
【文章页数】：6 页
【部分图文】：
GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewas
SOD水平在大于胎龄儿中是显著增加的。这些数据都证明在巨大儿中确实存在氧化应激失衡[20]。本研究并没有发现MDA水平与新生儿出生体重有关系，这与我们预期结果并不相符，因为过去的一项研究证明患有宫内生长发育迟缓（IUGR）的孕妇，其图1GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.图2GDM组与对照组GSH水平变化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.图3GDM组与对照组SOD水平变化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
图1GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.图2GDM组与对照组GSH水平变化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.图3GDM组与对照组SOD水平变化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
本文编号：3231940
【文章来源】：现代生物医学进展. 2019,19(01)
【文章页数】：6 页
【部分图文】：
GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewas
SOD水平在大于胎龄儿中是显著增加的。这些数据都证明在巨大儿中确实存在氧化应激失衡[20]。本研究并没有发现MDA水平与新生儿出生体重有关系，这与我们预期结果并不相符，因为过去的一项研究证明患有宫内生长发育迟缓（IUGR）的孕妇，其图1GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.图2GDM组与对照组GSH水平变化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.图3GDM组与对照组SOD水平变化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
图1GDM组与对照组MDA水平变化Fig.1MDAlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.643,P=0.0092.MDA,malondialdehyde;GDM,gestationaldiabetesmellitus.图2GDM组与对照组GSH水平变化Fig.2GSHlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.321,P=0.0217.GSH,glutathione;GDM,gestationaldiabetesmellitus.图3GDM组与对照组SOD水平变化Fig.3SODlevelinserumofGDMandhealthypregnanciesNote:Dataaregivenasthemean±SEM.Statisticalsignificancewasdeterminedusinganindependentttest.t=2.092,P=0.0397.SOD,superoxidedismutase;GDM,gestationaldiabetesmellitus.·54·
本文编号：3231940
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