慢性淋巴细胞白血病患者外周血调节性T细胞的百分率及与预后的关系

发布时间：2018-02-26 03:17

本文关键词： 调节性T细胞慢性淋巴细胞性白血病 Foxp 预后分析　出处：《细胞与分子免疫学杂志》2013年12期 　论文类型：期刊论文

【摘要】：目的探讨慢性淋巴细胞性白血病(CLL)患者外周血中调节性T细胞(Treg)表达及其与预后的相关性。方法采用流式细胞术检测30例健康体检者和28例初诊的CLL患者治疗前后外周血的CD4+CD25+Treg、CD4+CD25+Foxp3+Treg数量,并对19例患者进行了治疗随访。结果初诊CLL患者CD4+CD25+Treg高于健康对照组,差异有统计学意义(P0.05);初诊CLL患者CD4+CD25+Foxp3+Treg分别高于治疗后组和健康对照组,差异均有统计学意义(P0.05),治疗后CD4+CD25+Foxp3+Treg高于健康对照组,差异有统计学意义(P0.05)。初诊CLL患者CD4+CD25+Foxp3+Treg与CD38表达率、β2微球蛋白表达量、Zeta相关蛋白70(ZAP-70)阳性表达、临床Binet分期和Rai分期均呈正相关。结论 CD4+CD25+Foxp3+Treg有可能作为评估CLL患者疾病进展、疗效及预后的指标之一。
[Abstract]:Objective to investigate the expression of regulatory T cell tregs in peripheral blood of patients with chronic lymphoblastic leukemia (CLL) and its correlation with prognosis. Methods flow cytometry was used to detect 30 healthy controls and 28 newly diagnosed CLL patients before treatment. The number of CD4 CD25 Foxp3 Treg in peripheral blood of CD4 CD25 Tregmonium was determined. Results the CD4 CD25 Treg in the newly diagnosed CLL patients was higher than that in the healthy control group (P 0.05), the CD4 CD25 Foxp3 Treg in the newly diagnosed CLL patients was higher than that in the post-treatment group and the healthy control group. After treatment, the CD4 CD25 Foxp3 Treg was significantly higher than that in the healthy control group (P 0.05). The expression rate of CD4 CD25 Foxp3 Treg and CD38 and the expression of 尾 2 microglobulin in the newly diagnosed CLL patients were significantly higher than those in the healthy control group (P 0.05), and the expression of 尾 2 microglobulin and Zeta associated protein 70 (ZAP-70) were positive. Conclusion CD4 CD25 Foxp3 Treg may be one of the indexes to evaluate the disease progression, curative effect and prognosis of CLL patients.
【作者单位】：新疆医科大学第一附属医院血液科;
【基金】：新疆维吾尔自治区自然科学基金(2013211A100)
【分类号】：R392.11

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