E-Cadherin与干细胞的调控研究进展

发布时间：2018-03-20 10:45

本文选题：E-Cadherin　切入点：干细胞　出处：《中国矫形外科杂志》2013年24期 　论文类型：期刊论文

【摘要】：正干细胞是一类分化程度低,具有分化成不同类型细胞潜能且可自我更新的一类细胞。粘附分子是指由细胞产生、存在于细胞表面、介导细胞与细胞间或细胞与基质间相互接触和结合的一类分子。粘附分子可以使干细胞锚定于niche中,为干细胞-niche信号传递搭建平台,同时提供了极性线索引导干细胞分裂,对干细胞的对称和不对称分裂的选择及其连续、长期的自我更新起重要作用[1]。E-cadherin(上皮钙粘素)
[Abstract]:Positive stem cells are a class of cells with low differentiation, potential to differentiate into different types of cells and self-renewal. Adhesion molecules are produced by cells and exist on the surface of cells. A molecule that mediates the contact and binding between cells and cells or between cells and matrix. Adhesion molecules can anchor stem cells in niche, set up a platform for stem cell niche signal transduction, and provide polar clues to induce stem cell division. Selection and continuity of symmetric and asymmetric division of stem cells and long-term self-renewal plays an important role [1] .E-cadherin (E-cadherin)
【作者单位】：同济大学附属第十人民医院骨科;
【基金】：国家自然科学基金(编号:81271990)
【分类号】：R329

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