共刺激分子B7-H1参与肿瘤免疫的研究进展

发布时间：2018-06-23 04:48

本文选题：B-H + 肿瘤免疫逃逸　；参考：《细胞与分子免疫学杂志》2013年04期

【摘要】：B7-H1是继B7-1和B7-2之后发现的第3个B7家族分子。B7-H1可以抑制T淋巴细胞的增殖分化,促进调节性T细胞(Treg)的分化以及抑制性细胞因子的分泌,从而抑制免疫应答。B7-H1高表达于多种肿瘤细胞表面,它可通过与肿瘤浸润淋巴细胞上的相应受体结合,诱导淋巴细胞凋亡。因此高表达于肿瘤细胞的B7-H1可能参与了肿瘤的免疫逃逸过程。B7-Hl在肿瘤组织中的表达水平和肿瘤患者的临床病理特征及预后紧密相关。此外,B7-H1也参与上皮间质转化过程,提示该分子还可能与肿瘤的发生和转移有关。通过靶向干预B7-H1通路,有望重建肿瘤浸润淋巴细胞对肿瘤的免疫应答,抑制肿瘤的生长和转移,从而达到治疗肿瘤的目的,这一策略在临床实验中也取得了不错的效果。
[Abstract]:B7-H1 is the third B7 family molecule found after B7-1 and B7-2. B7-H1 can inhibit the proliferation and differentiation of T lymphocytes, promote the differentiation of regulatory T cells (Treg) and inhibit the secretion of cytokines. It can inhibit the expression of immune response. B7-H1 is highly expressed on the surface of various tumor cells. It can induce lymphocyte apoptosis by binding to the corresponding receptor on tumor infiltrating lymphocytes. Therefore, the overexpression of B7-H1 in tumor cells may be involved in the immune escape process of tumor. The expression level of B7-Hl in tumor tissues is closely related to the clinicopathological characteristics and prognosis of tumor patients. In addition, B7-H1 is also involved in the process of epithelial mesenchymal transformation, which suggests that B7-H1 may also be involved in tumorigenesis and metastasis. Through targeted intervention of B7-H1 pathway, it is expected to reconstruct the immune response of tumor infiltrating lymphocytes to tumor, inhibit tumor growth and metastasis, and thus achieve the purpose of tumor treatment. This strategy has also achieved good results in clinical trials.
【作者单位】：第四军医大学口腔医学系六队;第四军医大学肿瘤生物学国家重点实验室;第四军医大学免疫学教研室;
【基金】：国家自然科学基金(81171924)
【分类号】：R392.12

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