人脂肪基质细胞与骨再生——从实验室到临床

发布时间：2018-12-20 10:32

【摘要】：正骨缺损不仅严重影响患者的生活质量和身心健康,同时也给社会经济带来巨大负担。骨组织工程(bonetissue engineering)技术被认为是本世纪前沿的、有望为广大骨缺损患者带来福音的骨再生技术。人脂肪基质细胞或脂肪来源干细胞(human adipose-derived stromal cells,or human adipose-derived stem cells,hASCs)是存在于人体脂肪组织中、具有多向分化潜能的成体干细胞,与骨髓间充质干细胞(bone marrow mesenchy-mal stem cells,BMMSCs)相比,hASCs因其来源丰富、安全可靠、获取便捷、价格经济等优势,有望作为骨组织工程理想的种子细胞而成为近年来国内外骨再生研究的热点。这些研究为我们初步揭示了hASCs的成骨能力及成骨机制,也为尽快实现其临床转化奠定了理论基础,同时,将基于hASCs构建的组织工程骨应用于临床的实践也正在探索当中。
[Abstract]:Bone defects not only seriously affect the quality of life and physical and mental health of patients, but also bring a huge burden to the social economy. Bone tissue engineering (bonetissue engineering) is considered to be the leading technology in this century and it is expected to bring evangelical bone regeneration to the majority of bone defect patients. Human adipose stromal cells (HSCs) or adipose derived stem cells (human adipose-derived stromal cells,or human adipose-derived stem cells,hASCs) are adult stem cells with multiple differentiation potential in human adipose tissue. Compared with bone marrow mesenchymal stem cells (bone marrow mesenchy-mal stem cells,BMMSCs), hASCs has the advantages of abundant sources, safety and reliability, convenient access and economical price. It is expected to be an ideal seed cell for bone tissue engineering and become a hot spot in bone regeneration research at home and abroad in recent years. These studies have preliminarily revealed the osteogenic ability and mechanism of hASCs and laid a theoretical foundation for its clinical transformation as soon as possible. At the same time, the application of tissue-engineered bone based on hASCs in clinical practice is also being explored.
【作者单位】：北京大学口腔医学院·口腔医院修复科;
【基金】：国家自然科学基金(30200319、30901693、81170937、81070809) 新世纪优秀人才支持计划(BMU20110274)资助~~
【分类号】：R329

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