间充质干细胞系统:解析机体免疫调控和代谢平衡
发布时间：2019-02-16 17:00
【摘要】：间充质干细胞由于其独特的生物学特性和临床应用潜能,一直是干细胞研究的热点。这里,我首次提出间充质干细胞系统新概念:自胚胎发育早期,经历整个生长发育全过程的不同胚层、多个发育阶段,将亚全能间充质干细胞到不同等级分化潜能间充质干/祖细胞群体统称为MSC系统。MSC系统的确立具有重要意义:(1)赋予了MSC三大重要生物学特征,即干细胞自身特性、组织微环境功能及免疫调控功能;(2)平衡机体免疫与组织代谢;(3)提供高效转化为临床安全有效的组织特异性干细胞。总之,该系统很好的解释了间充质干细胞的异质性,同时丰富了我们之前提出的亚全能干细胞理论,为研究人员更好的理解间充质干细胞提供了深厚的理论平台。
[Abstract]:Mesenchymal stem cells (MSCs) have been the focus of stem cell research due to their unique biological characteristics and clinical application potential. Here, for the first time, I put forward a new concept of the mesenchymal stem cell system: from the early stage of embryonic development, it goes through different embryo layers, multiple stages of development throughout the whole process of growth and development. The subtotipotent mesenchymal stem cells into different differentiation potential mesenchymal stem / progenitor cell populations are collectively called MSC system. The establishment of MSC system is of great significance: (1) it gives MSC three important biological characteristics, namely stem cells' own characteristics. Tissue microenvironment function and immune regulation function; (2) to balance immune and tissue metabolism, and (3) to provide highly efficient tissue specific stem cells for clinical application. In a word, the system can explain the heterogeneity of mesenchymal stem cells and enrich the theory of sub-totipotent stem cells, which provides a profound theoretical platform for researchers to better understand mesenchymal stem cells.
【作者单位】： 北京协和医学院、中国医学科学院基础医学研究所组织工程中心协和医院;
【基金】：国家重大科学研究计划(973)(编号2011CB964900) 国家863项目(编号2011AA020100)
【分类号】：R392.1
，
本文编号：2424652
[Abstract]:Mesenchymal stem cells (MSCs) have been the focus of stem cell research due to their unique biological characteristics and clinical application potential. Here, for the first time, I put forward a new concept of the mesenchymal stem cell system: from the early stage of embryonic development, it goes through different embryo layers, multiple stages of development throughout the whole process of growth and development. The subtotipotent mesenchymal stem cells into different differentiation potential mesenchymal stem / progenitor cell populations are collectively called MSC system. The establishment of MSC system is of great significance: (1) it gives MSC three important biological characteristics, namely stem cells' own characteristics. Tissue microenvironment function and immune regulation function; (2) to balance immune and tissue metabolism, and (3) to provide highly efficient tissue specific stem cells for clinical application. In a word, the system can explain the heterogeneity of mesenchymal stem cells and enrich the theory of sub-totipotent stem cells, which provides a profound theoretical platform for researchers to better understand mesenchymal stem cells.
【作者单位】： 北京协和医学院、中国医学科学院基础医学研究所组织工程中心协和医院;
【基金】：国家重大科学研究计划(973)(编号2011CB964900) 国家863项目(编号2011AA020100)
【分类号】：R392.1
，
本文编号：2424652
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