急性脑梗死患者血小板超微结构及相关参数变化的研究

发布时间：2018-01-17 23:27

本文关键词：急性脑梗死患者血小板超微结构及相关参数变化的研究　出处：《浙江医学》2016年02期 　论文类型：期刊论文

【摘要】：目的探讨急性脑梗死患者血小板超微结构及血小板相关参数的表达及意义。方法选择发病在6~24h的脑梗死患者30例为实验组,健康体检者30例为对照组,采用透射电镜观察血小板超微结构,比较两组患者之间的差异;采用全自动血细胞分析仪检测血小板平均体积(MPV)、血小板计数(PLT),并对血小板相关参数进行分析。结果实验组及对照组的MPV分别为(9.18±0.57)、(8.76±1.32)fl,(P0.05),PLT分别为[(173.75±62.18)×10~9/L]、[(231.86±58.25)×10~9/L],(P0.05);透射电镜下,实验组患者血小板形态不规则,伪足增多,多处可见血小板聚集、融合在一起,成片状;血小板膜多处破裂;颗粒明显减少,线粒体肿胀、空泡化。对照组血小板均匀分散存在、呈圆型或椭圆型,血小板膜表面光滑,伪足突起很少,α颗粒和线粒体较多,少有空泡样改变。结论急性脑梗死患者MPV升高,PLT下降,血小板超微结构显著改变,是导致脑血管急性事件的血小板病理改变基础。
[Abstract]:Objective to investigate the expression and significance of platelet ultrastructure and platelet related parameters in patients with acute cerebral infarction. The ultrastructure of platelet was observed by transmission electron microscope (TEM) in 30 healthy persons as control group and the difference between the two groups was compared. The mean platelet volume (MPV) and platelet count (PLT) were measured by automatic blood cell analyzer. Results the MPV of the experimental group and the control group were 9.18 卤0.57 and 8.76 卤1.32, respectively. [173.75 卤62.18) 脳 10 9 / L], [(231.86 卤58.25) 脳 10 ~ (9 / L); Under the transmission electron microscope, the patients in the experimental group were irregular in shape, pseudopodia increased, platelet aggregation was seen in many places, fusion into a piece; Multiple rupture of platelet membrane; The platelets in the control group were evenly dispersed, round or elliptical, the surface of platelet membrane was smooth, there were few pseudopodia protrusions, and there were more 伪 particles and mitochondria in the control group. Conclusion the increase of MPV in patients with acute cerebral infarction and the significant changes in ultrastructure of platelets are the basis for the pathological changes of platelets in patients with acute cerebral infarction.
【作者单位】：衢州市人民医院、浙江中医药大学附属衢州中心医院神经内科;浙江大学医学院附属第二医院神经内科;
【分类号】：R743.3
【正文快照】： 脑梗死是脑血管疾病的最常见类型,是导致人类死亡的主要疾病之一[1]。脑梗死的发生、发展是一个复杂的病变过程,部分发病机制尚不完全清楚[\关于脑梗死患者外周血中血小板活化状态、功能变化的研究已取得了一些进展,但国内外对脑梗死患者血小板超微结构变化这一重要发病机制环

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