阿替普酶治疗急性脑梗死的疗效观察

发布时间：2018-01-21 17:27

本文关键词： 阿替普酶拜阿司匹林急性脑梗死静脉溶栓　出处：《天津医科大学》2014年硕士论文　论文类型：学位论文

【摘要】：目的：观察阿替普酶治疗急性脑梗死的临床疗效和安全性。方法：2011年6月—2013年6月在天津市环湖医院住院的急性脑梗死患者80例随机分为治疗组(40例)和对照组(40例)。治疗组给予阿替普酶0.9mg/kg用量,总剂量的10%静脉推注,剩余剂量在随后60min内持续静脉滴注,24h后经头颅CT证实患者有无出血。在两组患者治疗前、治疗后1、3、7、30、90d进行欧洲卒中神经功能缺损程度(ESS)评分和Barthel指数评分。结果：两组治疗后患者神经功能均得到不同程度的改善,和治疗前相比,两组患者治疗后3、7、30、90d的ESS平均值均较治疗前有显著提高,治疗前后差异有统计学意义(P0.05)；治疗后,治疗组较对照组升高更明显,两组差异有统计学意义(P0.05)。两组治疗后Barthel指数较治疗前均明显提高,治疗前后差异有统计学意义(P0.05)；治疗1d后两组Barthel指数差异无统计学意义,但治疗3、7、30、90d后治疗组Barthel指数平均值明显高于对照组,差异有统计学意义(P0.05)。结论：阿替普酶治疗急性脑梗死能够显著改善进展性脑梗死患者的神经功能缺损症状,提高日常生活活动能力,疗效显著。
[Abstract]:Objective: to observe the clinical efficacy and safety of atropase in the treatment of acute cerebral infarction. Methods: from June 2011 to June 2013, 80 patients with acute cerebral infarction were randomly divided into treatment group (n = 40) and control group (n = 40). In the treatment group, the dosage of atropase was 0.9mg / kg. 10% of the total dose was injected intravenously, and the remaining dose was continuously infused within 60 minutes after 24 hours of continuous intravenous drip. After 24 hours of continuous intravenous drip, the patients were confirmed by cranial CT to be haemorrhagic or not. European neurologic deficit scale (ESS) and Barthel index were evaluated at 30 d and 90 d. Results: the neurological function of the patients in the two groups were improved in different degrees after treatment. Compared with before treatment, the average ESS of the patients in the two groups was significantly higher than that before treatment. The difference before and after treatment was statistically significant (P 0.05). After treatment, the treatment group than the control group increased significantly, the difference between the two groups was statistically significant (P 0.05). The two groups after treatment Barthel index was significantly higher than before treatment. The difference before and after treatment was statistically significant (P 0.05). There was no significant difference in Barthel index between the two groups after one day of treatment, but the average Barthel index of the treatment group was significantly higher than that of the control group after 30 days of treatment. The difference was statistically significant (P 0.05). Conclusion: the treatment of acute cerebral infarction with atropase can significantly improve the neurological deficit symptoms of patients with progressive cerebral infarction, improve the ability of daily life, and the curative effect is remarkable.
【学位授予单位】：天津医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R743.3

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