丹参多酚酸盐治疗急性脑缺血的临床研究

发布时间：2018-01-19 05:20

本文关键词： 丹参多酚酸盐急性脑缺血　出处：《实用药物与临床》2013年02期 　论文类型：期刊论文

【摘要】：目的探讨丹参多酚酸盐治疗急性脑缺血患者的临床疗效。方法将96例急性脑缺血患者随机分为治疗1组、治疗2组、对照组,各32例,对照组采用常规治疗:抗血小板、脑保护剂及改善脑循环、血压控制等;治疗1组在常规治疗的基础上加用丹参多酚酸盐100 mg/d静脉滴注,共治疗14 d;治疗2组在常规治疗的基础上加用丹参多酚酸盐200 mg/d静脉滴注,共治疗14 d。测定治疗前后三组患者的神经功能缺失评分(NDS)和日常生活活动能力评分(ADL)。结果治疗1组治疗前后NDS为(21.65±3.75)、(17.75±2.74)分,治疗2组为(21.28±4.08)、(15.43±3.057)分,对照组为(21.50±3.66)、(18.53±3.63)分,三组NDS均降低(P0.05),且治疗2组改善情况优于对照组(P0.05)。治疗1组治疗前后ADL评分分别为(24.21±3.12)、(58.23±5.31)分,治疗2组为(28.25±4.82)、(59.23±8.54)分,对照组为(29.53±4.51)、(55.78±8.55)分。三组治疗后ADL评分明显升高,但治疗2组较对照组升高明显(P0.05)。治疗2组总有效率(90.62%)高于对照组(68.75%)(P0.05)。结论中剂量丹参多酚酸盐可显著改善急性脑缺血患者的病情,值得临床推广。
[Abstract]:Objective to investigate the clinical efficacy of salvia miltiorrhiza polyphenolic acid in the treatment of acute cerebral ischemia. Methods 96 patients with acute cerebral ischemia were randomly divided into treatment group (n = 32), treatment group (n = 32) and control group (n = 32). The control group was treated with routine treatment: antiplatelet, cerebral protectant, improving cerebral circulation, blood pressure control, etc. Group 1 was treated with salvia miltiorrhiza polyphenolic acid 100 mg/d intravenous drip on the basis of routine treatment for 14 days. Group 2 was treated with salvia miltiorrhiza polyphenolic acid for 200 mg/d on the basis of routine treatment. After 14 days of treatment, the neurological deficit scores and ADL scores of the three groups were measured before and after treatment. Results the NDS of group 1 before and after treatment were (. 21.65 卤3.75). The scores were 17.75 卤2.74, 21.28 卤4.08, 15.43 卤3.057 in the treatment group and 21.50 卤3.66 in the control group. The NDS of the three groups was decreased by 18.53 卤3.63 (P 0.05). The improvement of the treatment group was better than that of the control group (P 0.05). The ADL score before and after treatment in the treatment group was 24.21 卤3.12 and 58.23 卤5.31, respectively. 59.23 卤8.54 in the treatment group and 29.53 卤4.51 in the control group. The score of ADL in the three groups was significantly higher after treatment than that in the control group (55.78 卤8.55). However, the total effective rate of treatment group 2 was significantly higher than that of control group (P 0.05), and the total effective rate of treatment group 2 was higher than that of control group (P 0.05). Conclusion moderate dose salvia miltiorrhiza polyphenolic acid can significantly improve the condition of patients with acute cerebral ischemia. It is worth popularizing in clinic.
【作者单位】：上海交通大学附属新华医院老年科;
【分类号】：R743.3
【正文快照】： 急性缺血性脑血管病是中老年患者的常见疾病,发病后引起神经元及神经胶质变性,脑实质软化、坏死,从而引起神经功能缺损,目前其发病率有逐年增加的趋势,致死率及致残率较高,严重影响患者的生活质量及预后。注射用丹参多酚酸盐是从单味中药丹参中提取所得,用于心绞痛患者已取得

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