NT-proBNP对重度烧伤患者心功能评价的临床意义

发布时间：2018-01-27 02:45

本文关键词： 重度烧伤 NT-proBNP 心功能评价临床意义　出处：《实用医学杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的:探讨N末端脑利钠肽(NT-proBNP)对重度烧伤患者心功能评价的临床意义。方法:选取在我院重症监护室(ICU)进行治疗的重度烧伤患者78例,按是否有心力衰竭发生分为心衰组(31例)和非心衰组(47例)。比较2组不同时间NT-proBNP水平变化情况、心功能指标、相关指标及病死率情况。结果:心衰组NT-proBNP、肌钙蛋白(CTnT)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、每博输出量指数(SVI)、心脏指数(CI)、中心静脉压(CVP)水平及急性生理学及慢性病健康状况(APACHE Ⅱ)评分较非心衰组明显提高,差异具有统计学意义(P0.05)心衰组平均动脉压(MAP)较非心衰组明显降低,差异具有统计学意义(P0.05);心衰组病死率较非心衰组明显升高,差异具有统计学意义(P0.05)。结论:心力衰竭是重度烧伤患者常见的并发症,且病死率较高,NT-proBNP可有效评估病情及预后情况。
[Abstract]:Objective: to investigate the clinical significance of N-terminal brain natriuretic peptide NT-proBNPs in evaluating cardiac function in patients with severe burn. Methods: ICU was selected in intensive care unit of our hospital. 78 cases of severe burn were treated. According to the occurrence of heart failure, there were 31 cases of heart failure group (n = 31) and 47 cases of non-heart failure group (n = 47). The changes of NT-proBNP level and cardiac function were compared between two groups at different time. Results: NT-proBNPs, cTnTnT, CK, CK-MBs were found in patients with heart failure. The scores of SVI, CI, CVP, acute physiology and chronic health status were significantly higher than those in the non-CHF group. The mean arterial pressure in heart failure group was significantly lower than that in non-heart failure group, and the difference was statistically significant (P 0.05). The mortality of heart failure group was significantly higher than that of non-heart failure group, and the difference was statistically significant (P 0.05). Conclusion: heart failure is a common complication in severe burn patients, and the mortality is higher. NT-proBNP can effectively evaluate the state of disease and prognosis.
【作者单位】：广东省深圳市宝安区人民医院烧伤整形科;
【分类号】：R541.6;R644
【正文快照】： BNP是一种多肽类心脏激素,心室为其主要分泌部位,而当容量负荷增加或心室壁张力增加将造成BNP水平增加[1-3]。NISHIKIMI[4]研究发现,血浆中BNP/NT-pro BNP水平能够很敏感地反映血流动力学变化,是心力衰竭、心肌梗死后心功能评价与预后判定方面的重要生化指标。临床实践表明[4]

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