急性脑梗死患者血清神经元特异性烯醇化酶和S100β含量与核磁弥散加权成像的对比

发布时间：2018-01-28 12:24

本文关键词： 急性脑梗死神经元特异性烯醇化酶 Sβ蛋白核磁弥散加权成像　出处：《中国老年学杂志》2016年20期 　论文类型：期刊论文

【摘要】：目的探讨神经元特异性烯醇化酶(NSE)和S100β蛋白水平在急性脑梗死临床应用中的可行性。方法选取2012~2014年在北华大学附属医院神经内科住院,符合急性脑梗死的诊断标准、发病在24 h内的78例患者,根据梗死面积分为小、中、大梗死组,行头部核磁弥散加权成像(MR-DWI)检查及血清NSE、S100β蛋白检测。对照组为我院健康体检人员40例。结果两组血清NSE、S100β蛋白水平有统计学差异(P0.001)。核磁弥散病灶大小与血清NSE、S100β水平均呈正相关(r=0.851,0.758;P0.05)。结论急性脑梗死患者血清NSE、S100β水平的变化能反映脑组织损伤的严重程度,可以作为急性脑梗死患者病情评估的一项重要指标,较影像学检查更方便、更经济、易于掌握。
[Abstract]:Objective to investigate the neuron-specific enolase (NSE). The feasibility of clinical application of S100 尾 protein in acute cerebral infarction methods from 2012 to 2014, we were hospitalized in Department of Neurology, affiliated Hospital of North China University. According to the diagnostic criteria of acute cerebral infarction, 78 patients with acute cerebral infarction within 24 hours were divided into small, medium and large infarction groups according to the infarct size. Head magnetic diffusion weighted imaging (MR-DWI) and serum NSES100 尾 protein were examined. The control group consisted of 40 healthy persons in our hospital. Results Serum NSE was detected in both groups. The S100 尾 protein level was significantly different (P 0.001). There was a positive correlation between the size of nuclear magnetic diffusion lesion and the serum NSEP S100 尾 level. Conclusion the change of serum NSEP S100 尾 level in patients with acute cerebral infarction can reflect the severity of brain tissue injury, and it can be used as an important index to evaluate the condition of patients with acute cerebral infarction. It is more convenient, more economical and easier to master than imaging examination.
【作者单位】：北华大学附属医院神经二科;
【基金】：吉林省卫生厅课题(20132095)
【分类号】：R743.3
【正文快照】： 脑梗死后神经组织缺血、缺氧导致中枢神经系统(CNS)病变时,与神经系统有关的蛋白出现异常变化。有研究显示,神经元特异性烯醇化酶(NSE)、S100β蛋白分别为神经元、脑胶质细胞的特异性蛋白,在缺血性脑血管病变时均有不同程度升高,其升高程度与病情严重程度及预后密切相关,并可

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