急性脑梗死患者体内血小板CD62P和sTLT-1的表达水平

发布时间：2018-01-31 00:31

本文关键词： 急性脑梗死动脉粥样硬化性血栓形成血小板 CDP sTLT-　出处：《中风与神经疾病杂志》2017年02期 　论文类型：期刊论文

【摘要】：目的大量研究表明血小板CD62P和sTLT-1能够促进动脉粥样硬化性血栓的形成,因此我们检测急性脑梗死患者体内血小板CD62P和sTLT-1的表达水平,以作为评价动脉粥样硬化性血栓形成的功能指标。方法选择急性脑梗死患者(发病时间≤7 d)102例作为病例组,同期选择来我科就诊的非急性脑梗死患者93例为对照组,采用流式细胞仪(flow cytometry,FCM)检测血小板CD62P的表达水平,用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测血清中sTLT-1的表达水平。结果急性脑梗死组的血小板CD62P和sTLT-1的表达水平均明显高于对照组(P0.01),CD62P和sTLT-1的表达水平与急性脑梗死患者的神经功能缺损程度及梗死灶体积呈正相关;CD62P和sTLT-1之间呈直线正相关(r=0.247,P0.01);多元Logistic回归分析,CD62P和sTLT-1在校正其他相关危险因素后[CD62P(%)OR值=1.102,95%CI:1.062~1.143,P0.01;sTLT-1(pg/ml)OR值=1.004,95%CI:1.002~1.006,P0.01]。结论血小板CD62P和sTLT-1是脑梗死发病的危险因素,可能是急性脑梗死患者体内动脉粥样硬化性血栓形成的独立危险因素。
[Abstract]:Objective to study shows that a large number of platelet CD62P and sTLT-1 can promote the formation of atherosclerotic thrombosis, we detect the expression of acute platelet CD62P in patients with cerebral infarction and sTLT-1, as a function evaluation index of atherosclerotic thrombosis. Methods the patients with acute cerebral infarction (onset within 7 d) and 102 cases as case group, select the same period of non acute in patients with cerebral infarction in our hospital from 93 cases as control group, using flow cytometry (flow cytometry FCM) to detect the expression of platelet CD62P, using enzyme-linked immunosorbent assay (enzyme linked immunosorbent assay, ELISA) to detect the expression of sTLT-1 in serum. The expression level of the acute cerebral infarction group of platelet CD62P and sTLT-1 the higher than in the control group (P0.01), neurological function of the patients the expression level of CD62P and sTLT-1 and acute cerebral infarction can damage And positively related to infarct volume; there was a positive linear correlation between CD62P and sTLT-1 (r=0.247, P0.01); multivariate Logistic regression analysis, CD62P and sTLT-1 in the correction of other related risk factors after [CD62P (%) OR =1.102,95%CI:1.062~1.143, P0.01; sTLT-1 (pg/ml) OR = 1.004,95%CI:1.002~1.006, P0.01]., CD62P and sTLT-1 conclusion platelet is a risk factor the incidence of cerebral infarction, may be an independent risk factor for acute cerebral infarction in patients with atherosclerotic thrombosis.

【作者单位】：内蒙古科技大学包头医学院第一附属医院神经内科;
【基金】：内蒙古科技大学包头医学院青苗计划项目(No.2016H0906)
【分类号】：R743.33
【正文快照】： 动脉粥样硬化性血栓形成是目前公认的脑梗死急性发病的主要原因,不稳定的粥样硬化斑块被侵蚀发生破裂后,富含脂质的核心和内皮下胶原等物质会激活血流中的血小板,活化的血小板通过变形、释放颗粒内容物及合成血管活性物质等作用,招募血流中的白细胞粘附于血管内皮损伤处,粘附

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