影响急性大动脉粥样硬化性脑梗死患者脑微出血严重程度的危险因素分析

发布时间：2018-02-09 07:13

本文关键词： 脑梗死大动脉粥样硬化性脑微出血甘油三酯尿酸同型半胱氨酸血深部白质高信号　出处：《中风与神经疾病杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的探讨影响急性大动脉粥样硬化性脑梗死患者脑微出血(CMBs)严重程度的危险因素。方法收集2013年7月-2015年1月南京医科大学附属南京医院神经内科住院的TOAST分型为大动脉粥样硬化性的急性脑梗死患者112例,经磁共振磁敏感加权成像(SWI)证实有CMBs的患者56例。根据SWI上CMBs的病灶数,分为1级组9例,2级组28例,3级组19例。收集各组患者病史、一般临床资料、血生化结果及头部MRI,对两组资料进行单因素分析和相关性分析。结果单因素分析结果显示,脑微出血严重程度随着甘油三酯水平的增高而降低,随着同型半胱氨酸水平的增高而增高,随着尿酸水平的增高而增高,随着深部白质高信号Fazekas’s分级的增高而增高,3组间差异有统计学意义(P0.05)。Spearman秩相关分析显示,脑微出血严重程度与甘油三酯水平呈负相关(r=-0.443,P=0.001);与尿酸水平、同型半胱氨酸水平及深部白质高信号Fazekas’s分级呈正相关(r=0.325,P=0.015;r=0.491,P=0.001;r=0.334,P=0.009)。结论甘油三酯、尿酸、同型半胱氨酸水平及深部白质高信号Fazekas’s分级与急性大动脉粥样硬化性脑梗死患者CMBs的严重程度相关。
[Abstract]:Objective to investigate the risk factors affecting the severity of cerebral microhemorrhage in patients with acute atherosclerotic cerebral infarction (ACI). Methods TOAST typing was collected from July 2013 to January 2015 in the Department of Neurology, Nanjing Hospital affiliated to Nanjing Medical University. For 112 patients with acute cerebral infarction caused by atherosclerosis, 56 patients with CMBs were confirmed by magnetic resonance magnetic sensitivity weighted imaging (MRI). According to the number of CMBs lesions on SWI, they were divided into 1 grade group (9 cases) and 2 grade group (28 cases) and 3 grade group (19 cases). The history and general clinical data of the patients in each group were collected. Blood biochemical results and head MRI were analyzed by univariate analysis and correlation analysis. Results the results of univariate analysis showed that the severity of cerebral microhemorrhage decreased with the increase of triglyceride level. With the increase of homocysteine level and uric acid level, and with the increase of high signal Fazekas's grade in deep white matter, the difference among the three groups was statistically significant (P 0.05). Spearman rank correlation analysis showed that there was no significant difference among the three groups. The severity of intracerebral microhemorrhage was negatively correlated with triglyceride level, and positively correlated with uric acid level, homocysteine level and high signal Fazekas's classification in deep white matter. Conclusion triglyceride, uric acid, uric acid, triglyceride, uric acid, and hyperintense Fazekas's grade are positively correlated with the severity of intracerebral microhemorrhage. Conclusion there is a positive correlation between the severity of cerebral microhemorrhage and the level of triglyceride, uric acid, and the classification of hyperintense Fazekas's in the deep white matter. Conclusion the level of triglyceride, uric acid, and uric acid are positively correlated with the severity of intracerebral microhemorrhage. The level of homocysteine and the high signal Fazekas's grade in the deep white matter were correlated with the severity of CMBs in patients with acute atherosclerotic cerebral infarction.
【作者单位】：南京医科大学附属南京医院神经内科;
【基金】：国家自然科学基金(No.81500916)
【分类号】：R743.34

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