不同剂量去甲肾上腺素对感染性休克患者血流动力学参数与预后的影响

发布时间：2018-02-28 17:43

本文关键词： 不同剂量去甲肾上腺素感染性休克　出处：《中华医院感染学杂志》2016年08期 　论文类型：期刊论文

【摘要】：目的探讨不同剂量去甲肾上腺素对感染性休克患者血流动力学参数及其预后的影响,为去甲肾上腺素剂量的选择提供参考依据。方法选取2012年3月-2014年8月医院收治的感染性休克患者162例为研究对象,采用数字随机法分为大剂量组和常规剂量组,各81例;大剂量组患者在常规治疗的基础上静脉滴注去甲肾上腺素0.20μg/(kg·min),常规剂量组患者在常规治疗的基础上静脉滴注去甲肾上腺素0.1μg/(kg·min),对比两组患者不良反应,数据采用SPSS 19.0软件进行统计分析。结果大剂量组患者不良反应总发生率为14.8%,高于常规剂量组的4.9%,差异有统计学意义(P0.05)。结论不同剂量去甲肾上腺素均可改善感染性休克患者血流动力学,而盲目增加去甲肾上腺素用量,不但对其干预效果无明显影响,反而可造成较大不良反应发生,且影响患者预后。
[Abstract]:Objective to investigate the effects of different doses of norepinephrine on hemodynamic parameters and prognosis in patients with septic shock. Methods A total of 162 patients with septic shock from March 2012 to August 2014 were selected and randomly divided into two groups: high dose group and routine dose group (81 cases each). The patients in the high dose group were given norepinephrine 0.20 渭 g / kg 路min on the basis of routine treatment, and the patients in the routine dose group were given norepinephrine 0.1 渭 g / kg 路min on the basis of routine treatment. The adverse reactions were compared between the two groups. The data were analyzed by SPSS 19.0 software. Results the total incidence of adverse reactions in high dose group was 14. 8, which was higher than that in routine dose group (4. 9). The difference was statistically significant (P 0. 05). Conclusion different doses of norepinephrine can improve infection. Hemodynamics in patients with shock, Blindly increasing the dosage of norepinephrine not only had no obvious effect on the intervention effect, but also caused a large adverse reaction and affected the prognosis of the patients.
【作者单位】：重庆市涪陵中心医院重症医学科;
【基金】：重庆市卫计委科研基金资助项目(20142166)
【分类号】：R459.7

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