外周血PCT水平检测对急性百草枯中毒患者预后的预测价值

发布时间：2018-03-02 11:51

  本文选题：急性百草枯中毒　切入点：降钙素原　出处：《山东医药》2017年29期 　论文类型：期刊论文

【摘要】：目的探讨外周血降钙素原(PCT)水平检测对急性百草枯中毒患者预后的预测价值。方法急性百草枯中毒患者89例,根据患者中毒后1个月的预后状况分为生存组(59例)和死亡组(30例),比较生存组和死亡组患者的口服百草枯剂量、口服百草枯浓度、PCT、C反应蛋白(CRP)、白细胞(WBC)和丙氨酸氨基转移酶(ALT)差异,并利用Pearson相关性分析PCT水平与上述各指标的关系,ROC曲线评析PCT水平预测1个月内死亡事件发生的价值。结果与生存组相比,死亡组口服百草枯剂量、口服百草枯浓度、PCT、CRP、WBC和ALT均高(P均0.05)。外周血PCT水平与CRP、WBC、ALT、口服百草枯剂量和口服百草枯浓度存在正相关(P均0.05);ROC曲线结果显示:当PCT≥0.90μg/L时,判断急性百草枯中毒患者1个月内死亡事件发生的灵敏度为90.00%,特异度为50.85%,曲线下面积为0.74,95%CI为0.64~0.85。结论外周血PCT水平检测对急性百草枯患者的预后有良好预测价值。
[Abstract]:Objective to study the prognostic value of serum procalcitonin (PCT) level in patients with acute paraquat poisoning. Methods 89 patients with acute paraquat poisoning were included in this study. According to the prognosis of one month after poisoning, the patients were divided into survival group (59 cases) and death group (30 cases). The difference of oral paraquat concentration (PCT) C-reactive protein (CRP), WBC) and alanine aminotransferase (alt) was observed. Pearson correlation analysis was used to analyze the relationship between PCT level and the above indexes. The value of PCT level in predicting the occurrence of death events within one month was evaluated. Results compared with the survival group, the oral paraquat dose in the dead group was higher than that in the control group. The levels of PCT in peripheral blood were significantly higher than those in the control group (P < 0.05). There was a positive correlation between the dose of paraquat and the concentration of paraquat by oral administration. The results showed that when PCT 鈮，

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