脓毒血症患者血清降钙素原与心肌肌钙蛋白Ⅰ动态变化及临床意义

发布时间：2018-03-02 09:38

本文关键词： 脓毒血症心肌肌钙蛋白降钙素原感染　出处：《中华医院感染学杂志》2016年10期 　论文类型：期刊论文

【摘要】：目的动态监测脓毒血症患者血清降钙素原(PCT)、心肌肌钙蛋白I(cTnI)水平变化及其临床意义,为脓毒血症患者临床治疗及预后评估提供参考。方法选择2012年1月-2015年6月医院心内科收治的80例脓毒血症患者为研究对象,设为脓毒血症组,对血液标本进行菌株分离鉴定;另选取80例一般感染患者为一般感染组,80名健康体检人员作为对照组,观察3组受试者入组后1、3、7d血清PCT、cTnI水平变化;采用SPSS21.0软件进行统计分析。结果 80例脓毒血症患者血培养阳性47例,检出病原菌51株,其中革兰阴性菌、革兰阳性菌分别占68.63%、31.37%;革兰阴性菌主要以鲍氏不动杆菌、肺炎克雷伯菌为主,革兰阳性菌主要以金黄色葡萄球菌为主;左室舒张末径、左房内径水平脓毒血症组一般感染组健康对照组(P0.05),左室射血分数、短轴缩短率水平脓毒血症组一般感染组健康对照组,组间比较差异均有统计学意义(P0.05);血培养阳性组第1、3、7天PCT水平均显著高于同期血培养阴性组(P0.05),血培养阳性组PCT、cTnI水平第1天第3天第7天(P0.05);各时间点血清PCT、cTnI水平脓毒血症组一般感染组健康对照组(P0.05)。结论脓毒血症患者血清PCT、cTnI水平明显升高,动态监测脓毒血症患者血清PCT、cTnI水平变化有助于病情监测及预后评估。
[Abstract]:Objective to dynamically monitor the changes of serum calcitonin procalcitonin (PCT) and cardiac troponin I (cTnI) levels in patients with sepsis and their clinical significance. Methods from January 2012 to June 2015, 80 patients with sepsis were selected as the study objects. The blood samples were isolated and identified. In addition, 80 patients with general infection were selected as the control group. The serum levels of PCTcTnI were observed on the 1st and 7th day after the entry of the three groups. Results 47 cases were positive in blood culture of 80 patients with sepsis, 51 strains of pathogenic bacteria were detected, of which gram-negative bacteria accounted for 68.633.37%, Gram-negative bacteria were mainly Acinetobacter baumannii, and Gram-positive bacteria were mainly Acinetobacter baumannii. Klebsiella pneumoniae was predominant, Gram-positive bacteria were mainly Staphylococcus aureus, left ventricular end-diastolic diameter, left atrial internal diameter level sepsis group, normal infection group, healthy control group, left ventricular ejection fraction, Short axis shortening rate level sepsis group, general infection group, healthy control group, The level of PCT in the positive blood culture group was significantly higher than that in the negative blood culture group in the same period (P0.05), the level of PCTcTnI in the positive blood culture group was P0.05 on the 3rd day of the first day, and the serum PCTcTnI level in the blood culture positive group was significantly higher than that in the blood culture negative group on the 7th day of the first day, and the serum PCTcTnI level in each time point was also significantly higher than that in the blood culture negative group. Conclusion the serum levels of PCTcTnI in patients with sepsis were significantly higher than those in normal controls. Dynamic monitoring of serum PCT cTnI levels in patients with sepsis is helpful for disease monitoring and prognosis evaluation.
【作者单位】：河北医科大学第一医院心内三科;
【基金】：河北省卫生厅科研基金资助项目(20130577)
【分类号】：R459.7

【相似文献】