阿托伐他汀对急性ST段抬高型心肌梗死患者外周血内皮祖细胞表面标志物表达的影响

发布时间：2018-03-02 08:29

本文关键词： ST段抬高型心肌梗死内皮祖细胞阿托伐他汀 CXC趋化因子受体血管内皮生长因子碱性成纤维细胞生长因子沉默信息调节因子　出处：《中国病理生理杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的:比较不同剂量的阿托伐他汀对急性ST段抬高型心肌梗死(ST-segment elevation myocardial infarction,STEMI)患者中内皮祖细胞(endothelial progenitor cells,EPCs)功能变化的影响。方法:选择确诊为STEMI的患者共40例,根据服用阿托伐他汀钙片的剂量不同,随机分为20 mg组及40 mg组。采用流式细胞术,在不同时点(服药前及服药后第5、10、15、20、30、60、90、120天)对STEMI患者的循环EPCs进行识别及量化分析,检测EPCs表面标志物CXC趋化因子受体(CXCR)4、血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)、沉默信息调节因子1(SIRT1)的表达。结果:第5天40 mg组细胞增殖力及CXCR4、VEGF、bFGF的表达高于20 mg组(P0.05);第10~120天20 mg组细胞增殖力及CXCR4、VEGF、bFGF的表达高于40 mg组(P0.05)。SIRT1在第30天前2组的表达差异无统计学显著性;在第30天后出现明显变化,第60天达高峰,随后呈下降趋势,各时点均可见20 mg组大于40 mg组(P0.05)。结论:在STEMI急性期,40 mg阿托伐他汀提升机体修复功能优于20mg。然而,长期低浓度的他汀治疗在改善血管内膜功能和促进血管新生作用方面优于高剂量。
[Abstract]:Objective: to compare the effects of different doses of Atto vastatin on the function of endothelial progenitor cells in patients with acute ST-segment elevation myocardial infarction. Methods: 40 patients with STEMI were selected. According to the dosages of Atto vastatin calcium tablets, they were randomly divided into 20 mg group and 40 mg group. Flow cytometry was used to identify and quantify the circulating EPCs of patients with STEMI at different time points (before and after treatment). The expression of CXC chemokine receptor (CXCR4), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGFN) and silencing signaling factor 1 (SIRT1) on the surface of EPCs were detected. The cell proliferation and the expression of CXCR4VEGFN bFGF in 20mg group were higher than those in 40 mg group (P 0.05N. SIRT1) on day 10120, and there was no significant difference in the expression of CXCR4VEGFN bFGF between the two groups before the 30th day. There were obvious changes after 30 days, reached the peak on the 60th day, and then showed a downward trend. At each time point, it can be seen that 20mg group is more than 40 mg group (P 0.05). Conclusion: in the acute phase of STEMI, 40 mg Atto vastatin can improve the repair function of the body better than 20 mg. However, there is no significant difference between the two groups. Long-term low-dose statins are superior to high-dose in improving intimal function and promoting angiogenesis.
【作者单位】：柳州市人民医院心血管内科;安徽医科大学公共卫生学院;
【基金】：广西壮族自治区卫计委科研基金资助项目(No.Z2014546)
【分类号】：R542.2+2;;R363

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