垂体后叶注射液联合注射用乌司他丁治疗严重肺挫伤的临床观察

发布时间：2018-03-03 10:33

  本文选题：垂体后叶注射液　切入点：注射用乌司他丁　出处：《中国药房》2017年17期 　论文类型：期刊论文

【摘要】：目的:探讨垂体后叶注射液联合注射用乌司他丁治疗严重肺挫伤的疗效和安全性。方法:采用回顾性研究方法,选择我院2015年1月-2016年5月收治的严重肺挫伤患者60例,按照治疗方案分为对照组和观察组,各30例。对照组患者给予注射用乌司他丁10万U加至0.9%氯化钠注射液100mL中静脉滴注,bid;观察组患者在对照组基础上给予垂体后叶注射液6U加至0.9%氯化钠注射液49mL中静脉泵注(初始速率为0.008U/min,之后调整为≤0.04U/min),bid。两组患者均治疗1周。观察两组患者治疗前后的呼吸频率、肺挫伤简易评分、X线胸片评分、动脉血气指标[氧分压(PaO_2)、二氧化碳分压(PaCO_2)、血氧饱和度(SaO_2)和氧合指数(PO_2/FiO_2)]、炎症指标[白细胞介素2(IL-2)、IL-6、IL-10、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)]水平及临床疗效,并记录不良反应发生情况。结果:治疗前,两组患者呼吸频率、肺挫伤简易评分、X线胸片评分、动脉血气指标、炎症指标水平比较,差异均无统计学意义(P0.05)。治疗后,两组患者呼吸频率、肺挫伤简易评分、X线胸片评分和IL-6、hs-CRP、TNF-α水平均降低,且观察组明显低于对照组,差异均有统计学意义(P0.05);两组患者PaO_2、PaCO_2、SaO_2、PO_2/FiO_2、IL-2、IL-10水平均明显升高,且观察组明显高于对照组,差异均有统计学意义(P0.05)。观察组临床总有效率(100%)明显高于对照组(86.67%),差异有统计学意义(P0.05)。对照组患者的不良反应发生率(13.33%)明显高于观察组(6.67%),差异有统计学意义(P0.05)。结论:垂体后叶注射液联合注射用乌司他丁对严重肺挫伤患者疗效较好,并能有效抑制机体炎症反应,且安全性较高。
[Abstract]:Objective: to investigate the efficacy and safety of posterior pituitary injection combined with ulinastatin injection in the treatment of severe pulmonary contusion. Methods: a retrospective study was conducted in 60 patients with severe pulmonary contusion from January 2015 to May 2016 in our hospital. According to the treatment plan, they were divided into two groups: control group and observation group. 30 cases each. The patients in the control group were given urinastatin 100,000 U for injection to 0.9% mL sodium chloride injection by intravenous drip, while the patients in the observation group were given 6 U injection of posterior pituitary lobe injection to 49 mL 0.9% sodium chloride injection on the basis of the control group. Intravenous infusion (initial rate 0.008 U / min, then adjusted to 鈮，

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