持续脑电双频指数监测在脓毒症脑病患者中的应用价值

发布时间：2018-03-04 19:53

本文选题：脓毒症性脑病　切入点：脑电双频指数　出处：《中国现代医学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的探讨持续性脑电双频指数(BIS)监测在脓毒症脑病(SAE)患者中的临床应用价值。方法采取随机区组法,将山东省胜利油田中心医院2011年4月-2014月4月收治的116例脓毒症患者按是否为脑病患者分为脓毒症脑病组(SAE)及非脓毒症脑病组(非SAE),比较两组BIS、PCT、S100β蛋白、GCS分数及APACHE-II分数差异,并就BIS与GCS分数及APACHE-II分数进行Pearson相关性分析,同时对以上指标在患者的差异进行比较。结果 SAE组PCT值(8.453±3.442)μg/L及S100β蛋白值(0.775±0.356)μg/L均高于非SAE组(4.775±2.874)μg/L、(0.146±0.096)μg/L,差异具有统计学意义(P0.05);同时,脓毒症脑病患者BIS与GCS及APACHE-II具有明显的相关性,相关系数分别为0.754及-0.657,而脓毒症患者则无明显相关性,此外,两组患者不同治疗结局下各项指数差异均具有统计学意义(P0.05)。结论对脓毒症患者实施持续BIS监测有利于早期确诊患者是否并发脓毒症脑病,并对治疗预后起到一定的预判作用,同时BIS与GCS及APACHE-II具有较好的相关性,若配合PCT及S100β表达水平,则有助于准确评估患者病情。
[Abstract]:Objective to evaluate the clinical value of continuous bispectral index (BIS) monitoring in patients with septic encephalopathy (SAE). From April 2011 to April in Shengli Oilfield, Shandong Province, 116 patients with sepsis were divided into septic encephalopathy group (SAE) and non-septic encephalopathy group (non-SAEN) according to whether they were encephalopathy. The difference of GCS scores and APACHE-II scores between the two groups was compared. The correlation between BIS, GCS score and APACHE-II score was analyzed by Pearson, and the differences of the above indexes in patients were compared. Results the PCT value of SAE group was 8.453 卤3.442) 渭 g / L and S100 尾 protein value was 0.775 卤0.356 渭 g / L, which was higher than that of non-#en6# group (4.775 卤2.874) 渭 g / L 0.146 卤0.096 渭 g / L, the difference was statistically significant (P 0.05). The correlation coefficient between BIS and GCS and APACHE-II was 0.754 and -0.657, respectively, but there was no significant correlation between GCS and APACHE-II in septic encephalopathy. Conclusion continuous BIS monitoring in sepsis patients is beneficial to the early diagnosis of sepsis encephalopathy, and plays a certain role in predicting the prognosis of the patients with sepsis, and the difference of indexes between the two groups under different treatment outcomes is statistically significant (P0.050.Conclusion continuous BIS monitoring is beneficial to the early diagnosis of patients with septic encephalopathy, and plays a role in predicting the prognosis of the patients. At the same time, BIS had good correlation with GCS and APACHE-II. If combined with the expression of PCT and S100 尾, it would be helpful to evaluate the patient's condition accurately.
【作者单位】：山东省胜利油田中心医院重症医学科;
【分类号】：R459.7

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