急性心力衰竭患者血清激活素A和B型钠尿肽水平变化及意义

发布时间：2018-03-13 09:32

本文选题：心力衰竭　切入点：激活素A　出处：《山东医药》2017年06期 　论文类型：期刊论文

【摘要】：目的观察急性心力衰竭患者血清激活素A(ACT-A)与B型钠尿肽(BNP)的水平变化,并探讨其临床意义。方法选择急性心力衰竭患者150例,其中心力衰竭轻度(A组)、中度(B组)、重度(C组)各50例,取同期年龄、性别相匹配的门诊健康查体者50例作为对照(D组)。对照组及观察组入院后24、72 h采静脉血,采用ELISA法检测血清ACT-A、双抗体夹心免疫荧光法检测BNP。结果 A、B、C组入院24、72 h血清ACT-A、BNP水平均高于D组,且A组B组C组,P均0.05;A、B、C组入院72 h血清ACT-A、BNP均较24 h时降低,P均0.05;急性心力衰竭患者入院后24、72 h血清ACT-A与BNP水平呈正相关(r分别为0.689、0.517,P均0.05)。结论急性心力衰竭患者血清ACT-A、BNP水平明显升高,且随心力衰竭程度加重逐渐升高,二者呈正相关;血清ACT-A、BNP参与心力衰竭的发生,并可反映病情严重程度。
[Abstract]:Objective to observe the changes of serum activin A (ACT-A) and type B natriuretic peptide (BNP) levels in patients with acute heart failure and to explore their clinical significance. Methods 150 patients with acute heart failure were selected. Among them, 50 cases in group A, 50 cases in group B, 50 cases in group C, and 50 cases in group D were taken as control group. Venous blood was collected from control group and observation group at 2472 hours after admission. Serum ACT-A and BNPs were detected by ELISA method and double antibody sandwich immunofluorescence method respectively. Results the serum ACT-An BNP levels in group A were higher than those in group D at 24 ~ 72 h after admission. In group A, the levels of ACT-A and BNP in group C were lower than those in group B at 72 h after admission, and the positive correlation between serum ACT-A and BNP in patients with acute heart failure was 0.689 卤0.517 (P = 0.05) at 24 h after admission. Conclusion the serum levels of ACT-ANABNP in group C are significantly lower than those in group C at 24 h after admission, and the levels of BNP in group C are significantly higher than those in group B at 24 h after admission. The BNP level of ACT-An was significantly increased. Serum ACT-An BNP was involved in the occurrence of heart failure and could reflect the severity of the disease.
【作者单位】：菏泽市牡丹人民医院;江苏省人民医院;
【分类号】：R541.6

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