脑心通胶囊对急性心肌梗死患者PCI后心肌灌注和血小板活化功能的影响

发布时间：2018-03-23 13:35

本文选题：脑心通胶囊　切入点：经皮冠状动脉介入治疗　出处：《中国药房》2016年27期

【摘要】：目的:观察脑心通胶囊对急性心肌梗死(AMI)患者行经皮冠状动脉介入治疗(PCI)后心肌灌注和血小板活化功能的影响。方法:100例AMI患者采用平行随机抽样法分为对照组与观察组,每组50例。对照组患者给予常规PCI治疗,术前嚼服阿司匹林300 mg+氯吡格雷300 mg,术后服用阿司匹林100 mg/d+氯吡格雷75 mg/d。观察组患者在对照组治疗基础上(支架释放后)加服脑心通胶囊2~4粒,每日3次。两组疗程均为7 d,观察期为1个月。观察并比较两组患者PCI后15 min心肌灌注分级(TMPG)情况,治疗前后的血小板活化功能指标[CD62P、CD63及单核细胞血小板聚集体(MPA)阳性表达率],观察期内主要心血管事件(MACE)和并发症以及不良反应发生情况。结果:治疗后,观察组患者TMPG灌注3级例数占比显著高于对照组,MACE发生率显著低于对照组,差异有统计学意义(P0.05);两组患者并发症发生率和不良反应发生率比较差异无统计学意义(P0.05)。治疗前,两组患者CD62P、CD63、MPA阳性表达率比较差异无统计学意义(P0.05);治疗后,两组患者CD62P、CD63、MPA阳性表达率显著低于同组治疗前,且观察组低于对照组,差异均有统计学意义(P0.05)。结论:脑心通胶囊可以迅速提高AMI患者PCI后血小板活化功能,改善TMPG灌注情况,降低MACE发生率,且不增加并发症发生率,安全性较好。
[Abstract]:Objective: to observe the effect of Naoxintong capsule on myocardial perfusion and platelet activation after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 50 cases in each group. The patients in the control group were treated with routine PCI. The patients in the observation group were treated with aspirin 300mg clopidogrel 300mg before operation and 75 mg / d of clopidogrel for 100 mg/d postoperatively. The patients in the observation group were treated with Naoxintong capsule (2g / d) on the basis of the treatment of the control group (after the release of the stent). Three times a day. The course of treatment was 7 days and the observation period was 1 month. The myocardial perfusion grade of 15 min after PCI was observed and compared between the two groups. The platelet activation function before and after treatment [positive expression rate of CD62PnCD63 and monocyte platelet aggregates (MPAs)], major cardiovascular events (MACEs), complications and adverse reactions during the period of treatment were observed. The incidence of TMPG perfusion grade 3 in the observation group was significantly higher than that in the control group (P 0.05), and there was no significant difference between the two groups in the incidence of complications and adverse reactions (P 0.05). There was no significant difference in the positive expression rate of CD62PfU CD63MPA between the two groups. After treatment, the positive expression rate of CD62Pnc-CD63MPA in the two groups was significantly lower than that in the same group and the observation group was lower than that in the control group, and the positive expression rate of CD63MPA in the observation group was lower than that in the control group. Conclusion: Naoxintong capsule can rapidly improve platelet activation function after PCI, improve TMPG perfusion, reduce the incidence of MACE, and do not increase the incidence of complications in patients with AMI.
【作者单位】：潍坊市益都中心医院烧伤儿外科;潍坊市益都中心医院介入治疗科;
【分类号】：R542.22

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