依达拉奉联合氯吡格雷对老年急性脑梗死患者炎性因子及预后的影响分析

发布时间：2018-03-27 19:23

本文选题：依达拉奉　切入点：氯吡格雷　出处：《中国地方病防治杂志》2017年02期

【摘要】：目的探讨分析依达拉奉联合氯吡格雷对老年急性脑梗死患者炎性因子及预后的影响。方法选择本院收治的83例老年急性脑梗死患者,将其随机分为观察组43例、对照组40例,对照组患者给予氯吡格雷治疗,观察组给予依达拉奉联合氯吡格雷治疗,比较两组治疗前后神经功能缺损评分(NIHSS)、C反应蛋白(CRP)、白介素-6(IL-6)、肿瘤坏死因子(TNF-α)以及不良反应发生情况。结果观察组治疗总有效率显著高于对照组,差异具有统计学意义(P0.05);治疗7 d、治疗14 d两组患者NIHSS评分均较治疗前显著降低(P0.05),且观察组降低程度显著显著优于对照组(P0.05);治疗后两组患者血清hs-CRP、IL-6以及TNF-α均较治疗前显著降低(P0.05),且治疗后观察组患者血清hs-CRP、IL-6以及TNF-α均显著低于对照组(P0.05)。结论依达拉奉联合氯吡格雷治疗老年急性脑梗死疗效疗效显著,可有效改善患者的神经功能缺损,可显著降低患者血清hs-CRP、IL-6以及TNF-α水平,表明依达拉奉联合氯吡格雷对急性脑梗死的治疗作用可能与减轻患者机体炎症反应密切相关。
[Abstract]:Objective to investigate the effect of Edaravone combined with clopidogrel on inflammatory factors and prognosis in elderly patients with acute cerebral infarction. Methods 83 elderly patients with acute cerebral infarction were randomly divided into observation group (n = 43) and control group (n = 40). The patients in the control group were treated with clopidogrel, and the patients in the observation group were treated with Edaravone combined with clopidogrel. Before and after treatment, the neurological impairment score (NIHSS) and the incidence of CRPX, IL-6, TNF- 伪, TNF- 伪 were compared between the two groups. Results the total effective rate of treatment in the observation group was significantly higher than that in the control group. The NIHSS scores of the two groups were significantly lower than that of the control group on the 7th day and 14th day after treatment, and the degree of the decrease in the observation group was significantly better than that in the control group, and the serum hs-CRPIL-6 and TNF- 伪 were significantly higher in the observation group than in the treatment group. The serum levels of hs-CRPnIL-6 and TNF- 伪 in the observation group were significantly lower than those in the control group (P 0.05). Conclusion Edaravone combined with clopidogrel is effective in the treatment of elderly patients with acute cerebral infarction. It can effectively improve the neurological function of the patients and decrease the serum levels of hs-CRPU IL-6 and TNF- 伪, indicating that the therapeutic effect of Edaravone combined with clopidogrel on acute cerebral infarction may be closely related to alleviating the inflammatory reaction of the patients.
【作者单位】：郑州大学第二附属医院;
【基金】：河南省卫生厅中青年科技创新人才,编号:201004125
【分类号】：R743.33

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