外周血Th22在脓毒症患者中的水平变化及临床意义

发布时间：2018-04-02 23:25

  本文选题：脓毒症　切入点：诊断　出处：《重庆医学》2017年33期

【摘要】：目的探讨外周血Th22在脓毒症患者中的水平变化及其临床意义。方法选取2014年4月至2017年4月在该院就诊的脓毒症患者180例为研究对象,根据病情严重程度将其分为普通脓毒症组81例、严重脓毒症组68例和脓毒症休克组31例,另选取60例健康体检者为对照。检测各组外周血Th22、白细胞介素(IL)-22、IL-6及降钙素原(PCT)水平,记录急性生理与慢性健康状况(APACHEⅡ)评分情况,采用受试者工作特征(ROC)曲线评估外周血Th22对脓毒症早期诊断的价值。结果脓毒症患者外周血Th22和IL-22水平明显高于对照组(P0.05)。普通脓毒症组、严重脓毒症组及脓毒症休克组患者外周血Th22、IL-22、APACHEⅡ评分及PCT水平比较,差异有统计学意义(P0.05)。相关性分析显示,外周血Th22与PCT、APACHEⅡ评分呈正相关(r=0.80、0.66,P0.01)。外周血Th22=1.9%时,其敏感性和特异性分别为83.1%和85.2%,明显优于PCT。结论外周血Th22及其相关细胞因子对脓毒症患者早期诊断及病情严重程度的评估具有重要的临床价值。
[Abstract]:Objective to investigate the level of peripheral blood Th22 in patients with sepsis and its clinical significance.Methods 180 patients with sepsis from April 2014 to April 2017 were divided into general sepsis group (n = 81), severe sepsis group (n = 68) and septic shock group (n = 31).Another 60 healthy persons were selected as control.The levels of Th22, IL-6 and procalcitonin in peripheral blood of each group were measured, and the acute physiological and chronic health status (Apache 鈪，

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