急性脑梗死患者血清低氧诱导因子-1α与血管内皮生长因子水平及意义

发布时间：2018-04-05 11:39

本文选题：急性脑梗死　切入点：低氧诱导因子α　出处：《中国老年学杂志》2016年21期

【摘要】：目的探讨低氧诱导因子(HIF)-1α与血管内皮生长因子(VEGF)在急性脑梗死患者血清中的水平变化及临床意义。方法将脑梗死患者根据脑梗死灶面积分为大梗死灶、中梗死灶和小梗死灶,采用ELISA检测脑梗死血清HIF-1α与VEGF蛋白浓度,分析脑梗死急性期血清中HIF-1α和VEGF浓度在1、3、5、7、14 d动态变化水平,比较脑梗死不同体积组血清HIF-1α和VEGF的浓度。结果血清中HIF-1α浓度表达呈现动态变化规律,发病后1天达到高峰,之后呈现迅速下降趋势,1、3、5、7 d与对照组比较差异显著,14 d时虽没达到显著水平,但仍然高于对照组水平;不同体积脑梗死血清HIF-1α浓度比较,发现大梗死灶在各个时间点血清HIF-1α浓度均显著高于中梗死灶和小梗死灶,中梗死灶各个时间点平均血清HIF-1α浓度与小梗死灶只有1 d达到显著差异(P0.05或P0.01);脑梗死组血清VEGF浓度在5个时间点与对照组比较差异显著(P0.01),血清中VEGF浓度在发病后第5天达到高峰,在第14天仍然显著高于对照组(P0.01),大梗死灶和中梗死灶组在各个时间点血清VEGF浓度均显著高于小梗死灶(P0.05),大梗死灶与中梗死灶各个时间点血清VEGF浓度均未达到显著差异(P0.05)。结论血清HIF-1α和VEGF浓度在1、3、5、7 d与对照组比较差异显著,14 d时仍高于对照组,大梗死灶和中梗死灶组在各个时间点血清VEGF浓度均显著高于小梗死灶。
[Abstract]:Objective to investigate the expression of hypoxia inducible factor (HIF) -1 alpha and vascular endothelial growth factor (VEGF) levels in serum of patients with acute cerebral infarction and its clinical significance in patients with cerebral infarction. Methods according to the infarction area is divided into large infarcts in the infarct and small infarct, cerebral infarction was detected by ELISA HIF-1 alpha and VEGF protein concentration in serum analysis of acute cerebral infarction, the serum level of HIF-1 alpha and VEGF concentration of 1,3,5,7,14 in the dynamic change of D level, the concentration of alpha and VEGF in serum of different volume of HIF-1 compared to cerebral infarction. Results serum HIF-1 concentrations showed a dynamic change rule, reaching the peak at 1 days after the onset, after a rapid decline, 1,3,5,7 D compared with the control group significant differences, 14 d did not reach significant level, but still higher than the level of control group; compare the different volume of cerebral infarction and serum HIF-1 concentrations, found in large infarct in each time point of serum HIF- 1 alpha concentrations were significantly higher than those in the infarct and small infarction, infarction in each time point average serum HIF-1 concentration and small infarct only 1 D significant difference (P0.05 or P0.01); cerebral infarction group serum VEGF concentration at 5 time points significantly compared with the control group (P0.01), the concentration of VEGF in serum in fifth days after the onset of peak in Fourteenth days is still significantly higher than the control group (P0.01), large infarction and infarction group at each time point of serum VEGF concentration were significantly higher than that of small infarcts (P0.05), large infarction and infarction each time point serum VEGF concentrations were not significantly different (P0.05). Conclusion the serum HIF-1 and VEGF concentration significantly in 1,3,5,7 D compared with the control group, 14 d is still higher than the control group, and the infarct in large infarct group at each time point of serum VEGF concentration were significantly higher than that of small infarcts.

【作者单位】：华中科技大学同济医学院附属梨园医院神经内科;
【基金】：湖北省自然科学基金(No.201282723hb)
【分类号】：R743.33

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