颅脑损伤患者入院后不同时间段血清中Tau蛋白浓度的诊断价值

发布时间：2018-04-05 12:23

本文选题：颅脑损伤　切入点：Tau蛋白　出处：《广东医学》2017年02期

【摘要】：目的通过检测颅脑损伤(TBI)患者入院后不同时间段血清中的Tau蛋白浓度,对照比较TBI患者标准化治疗后的预后情况。方法筛选无TBI及相关颅脑疾病的体检者为对照组,检测对照组血清中Tau蛋白的浓度。收集临床确诊的TBI患者76例,于伤后的6 h及1、3、7 d分别采集患者血清标本。通过ELISA法分别检测对应时间段内的血清Tau蛋白浓度。于患者入院标准化治疗1个月后进行随访或复诊计算患者预后分数(通过Barthel指数评分计算)。应用SPSS统计软件对患者血清中Tau浓度、GCS评分、Barthel指数评分进行相关性分析。结果各TBI组血清Tau蛋白浓度与对照组相比较,差异有统计学意义(P0.05);重型组与轻中型组相比较,其血清Tau蛋白浓度差异有统计学意义(P0.05)。重型组患者的预后明显差于轻中型组。预后不同的各组血清中Tau蛋白浓度相比较,预后差组、预后中组、预后良组与对照组差异有统计学意义(P0.05);预后差组与预后中组、预后良组差异有统计学意义(P0.05);预后中组与预后良组差异无统计学意义(P0.05)。结论在发生TBI后,患者血清中Tau蛋白含量升高,升高的程度与TBI的严重程度呈正相关。TBI的程度与患者预后有关,损伤越重,患者预后越差。预后差患者与患者血清中Tau蛋白含量相关,Tau蛋白含量极高者预后差。
[Abstract]:Objective to detect the concentration of Tau protein in serum of patients with craniocerebral injury (TBI) at different time after admission, and to compare the prognosis of patients with TBI after standardized treatment.Methods the control group was selected as the control group without TBI and related craniocerebral diseases. The concentration of Tau protein in serum of the control group was detected.The serum samples of 76 patients with TBI were collected at 6 hours and 3 days after injury.The concentration of serum Tau protein was detected by ELISA method.The prognostic scores (calculated by Barthel index score) were calculated 1 month after admission to standardized therapy.The correlation between Tau and Barthel index was analyzed by SPSS software.Results compared with the control group, the concentration of serum Tau protein in the TBI group was significantly different from that in the control group (P 0.05), and the serum Tau protein concentration in the severe group was significantly higher than that in the light group (P 0.05).The prognosis of severe group was significantly worse than that of light and medium group.There were significant differences in serum Tau protein concentration between groups with different prognosis, poor prognosis group, prognosis group, good prognosis group and control group (P 0.05), poor prognosis group and prognosis group.There was significant difference between the good group and the good group (P 0.05), but there was no significant difference between the group with good prognosis and the group with good prognosis (P 0.05).Conclusion after the onset of TBI, the serum Tau protein level increases, and the degree of elevation is positively correlated with the severity of TBI. The degree of TBI is related to the prognosis of the patients. The more serious the injury, the worse the prognosis of the patients.The prognosis of patients with poor prognosis and patients with extremely high Tau protein content was poor.
【作者单位】：青海大学附属医院神经外科;
【基金】：青海省科技厅项目(编号:9632016Y0203)
【分类号】：R651.15

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