吸烟与重型颅脑损伤患者肺部感染发生率的关系

发布时间：2018-04-12 12:07

本文选题：吸烟 + 颅脑损伤　；参考：《宁夏医科大学》2013年硕士论文

【摘要】：目的：了解吸烟对重型颅脑损伤患者肺部感染及预后的影响，，为重型颅脑损伤患者的临床救治提供指导。方法：选择2006.1-2012.6入住宁夏医科大学总医院神经外科的早期脑疝患者236例，其中51例并发肺部感染，根据是否并发肺部感染将患者分为感染组和对照组，其中感染组共51例，对照组181例。两组病例之间在GCS评分与意识障碍的严重程度两方面采用方差分析没有统计学差异。两组病例之间气管切开方面采用卡方检验没有统计学差异。两组间性别运用卡方检验和年龄运用t检验均无统计学差异（P均＞0.05），具有可比性，两组患者病情严重程度，以及治疗方案上相对一致。将两组患者是否吸烟、吸烟时间以及吸烟量的情况进行统计。结果：感染组吸烟率为60.8%，对照组吸烟率为35.7%，两组间差异有统计学意义，P=0.001。单因素回归分析表明：吸烟者患病风险是不吸烟者的2.794倍。以小于等于5年、大于5年小于等于10年、大于10小于等于15年、大于15年将患者分为四组，两组间比较均存在统计学差异，P=0.001。单因素回归分析表明：吸烟年限提高五年患病风险是不吸烟者的1.39倍。吸烟量未见统计学差异。结论：吸烟是重型颅脑损伤患者肺部感染的危险因素，患者吸烟后颅脑损伤肺部感染风险比不吸烟患者提高。吸烟时间是重型颅脑损伤患者肺部感染的危险因素，随着吸烟时间增加，患者颅脑损伤后肺部感染风险提高。
[Abstract]:Objective: to investigate the effect of smoking on pulmonary infection and prognosis in patients with severe craniocerebral injury.Methods: 236 patients with early brain hernia admitted to the Neurosurgery Department of Ningxia Medical University General Hospital from June 2001 to June 2012.6 were selected. Among them, 51 cases were complicated with pulmonary infection. The patients were divided into infection group and control group according to whether they were complicated with pulmonary infection, among which 51 cases were infected group.Control group 181 cases.There was no statistical difference in GCS score and severity of consciousness disorder between the two groups.There was no statistical difference between the two groups in tracheotomy by chi-square test.There was no statistical difference between the two groups in sex use chi-square test and age use t test (P > 0.05), which was comparable. The severity of the disease and the treatment plan of the two groups were relatively consistent.The two groups of patients with smoking, smoking time and smoking volume were counted.Results: the smoking rate of the infected group was 60.8 and that of the control group was 35.7.The difference between the two groups was statistically significant.Univariate regression analysis showed that smokers were 2.794 times more at risk than non-smokers.The patients were divided into four groups: less than 5 years, more than 5 years less than 10 years, more than 10 less than 15 years, and more than 15 years. There was statistical difference between the two groups.Univariate regression analysis showed that smoking years increased the risk of disease by 1.39 times than that of non-smokers.There was no statistical difference in smoking.Conclusion: smoking is a risk factor for lung infection in patients with severe craniocerebral injury.Smoking time was a risk factor for lung infection in patients with severe craniocerebral injury. With the increase of smoking time, the risk of pulmonary infection increased after craniocerebral injury.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R651.15

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