和肽素对急性失代偿心力衰竭患者90天预后的预测价值
发布时间：2018-04-13 09:27
本文选题：心力衰竭 + 和肽素 ； 参考：《重庆医科大学》2013年硕士论文
【摘要】：研究目的： 探讨和肽素（copeptin）在急性失代偿性心力衰竭（AcuteDecompensated Heart Failure， ADHF）患者90天内发生不良事件的预测评估价值。 方法： 入选129例急性失代偿性心力衰竭患者，，测定血浆和肽素、N末端B型利钠肽原水平，采用心脏彩超测定左室射血分数，进行纽约心功能分级,并对所有患者连续随访90天，以心源性死亡或心力衰竭加重再入院为不良终点事件。评估和肽素对急性失代偿性心力衰竭患者90天不良终点事件的预测价值，并与NT-proBNP进行比较。 结果： 终点事件组47人、非终点事件组82人。终点事件组血浆copeptin、NT-proBNP水平均明显高于非终点事件组,差异有统计学意义（P 0.05）。受试者工作曲线下面积（Receiver operating characteristic，ROCs）分别为：copeptin0.602(SE，0.052；95%CI0.499-0.705)； NT-proBNP0.659(SE，0.048；95%CI0.565-0.753)；两者联合预测价值0.670(SE，0.050；95%CI0.573-0.767)，差异均无统计学意义（P㧐0.05）。 结论： 在急性失代偿性心力衰竭患者中，血浆copeptin水平对于患者发生心血管不良事件有预后评估价值，随访90天内血浆copeptin水平与NT-proBNP对预测不良终点事件价值相同，联合应用copeptin、NT-proBNP不能提高急性失代偿性心力衰竭患者90天的预后评估价值。
[Abstract]:Purpose of study :
To investigate the predictive value of copeptin in predicting adverse events within 90 days of patients with acute decompensated heart failure ( ADHF ) .
Method :
In 129 patients with acute decompensated heart failure , the levels of plasma and peptide , N - terminal B - type natriuretic peptide were measured , the left ventricular ejection fraction was measured by color Doppler ultrasound , the cardiac function in New York was graded , and the event of adverse endpoint was assessed by cardiac death or heart failure .
Results :
The plasma copeptin and NT - np levels in the terminal event group were significantly higher than those in the non - terminal event group ( P 0.05 ) . The area under the subject ' s working curve ( Receiver operating characteristic , ROCs ) was : copeptin0.602 ( SE , 0.052 ;
95 % CI 0.499 - 0.705 ) ;
NT-proBNP0.659(SE,0.048锛
本文编号：1743899
本文链接：https://www.wllwen.com/yixuelunwen/jjyx/1743899.html
最近更新
教材专著
