缺血性卒中急性期降压药物方案对卒中后认知障碍的影响

发布时间：2018-04-13 15:20

本文选题：脑梗死 + 高血压　；参考：《临床神经病学杂志》2017年03期

【摘要】：目的探讨缺血性卒中急性期不同降压方案对卒中后认知功能障碍(PSCI)的影响方法选取发病24 h内入院的首发缺血性脑卒中患者796例,按照高血压防治指南选取合理的降压方案并按其分组,对其认知功能进行1年的随访,采用logistics回归分析发病3个月时各降压方案与认知功能障碍之间的关系。结果以钙拮抗剂(CCB)+转换酶抑制剂(ACEI)+β-受体拮抗剂(βB)组为参照的logistics回归分析发现,单用药物组、四联降压组及其他组PSCI风险均显著高于参照组[CCB:OR=2.31,95%CI=1.22~4.39;ACEI:OR=3.07,95%CI=1.41~6.67;血管紧张素受体拮抗剂(ARB):OR=3.34,95%CI=1.40~7.96;CCB+ACEI+βB+D:OR=2.24,95%CI=1.04~5.67;CCB+ARB+βB+D:OR=2.50,95%CI=1.07~5.84;其他:OR=6.10,95%CI=1.72~21.61]。结论缺血性卒中急性期二联及三联降压方案对PSCI可能具有预防意义。
[Abstract]:Objective to investigate the therapy of acute ischemic stroke on cognitive impairment after stroke (PSCI) 796 first-episode patients with ischemic stroke. Methods were admitted within 24 h of onset were selected according to the reasonable antihypertensive therapy guidelines for hypertension prevention and treatment according to the grouping, followed up for 1 years on the cognitive function, using the logistics regression analysis of incidence the relationship between antihypertensive therapy and cognitive impairment in 3 months. The calcium antagonist (CCB) + converting enzyme inhibitor (ACEI) + beta receptor antagonist (beta B) group according to the logistics regression analysis found that single drug group, quadruple antihypertensive group and other group PSCI risk significantly higher than that of the control group [CCB:OR=2.31,95%CI=1.22~4.39; ACEI:OR=3.07,95%CI=1.41~6.67; angiotensin receptor antagonist (ARB): OR=3.34,95%CI=1.40~7.96; CCB+ACEI+ B+D:OR=2.24,95%CI=1.04~5.67 CCB+ARB+ B+D:OR=2.50,95 beta beta; %CI=1.07~5.84; others: OR=6.10,95%CI=1.72~21.61]. conclusion the two combined and triple hypotensive regimen for acute ischemic stroke may have a preventive effect on PSCI.

【作者单位】：徐州医科大学附属连云港医院神经内科;
【分类号】：R743.3

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