急性脑梗死患者血清miR-181c水平与认知功能受损的关系

发布时间：2018-04-18 15:37

本文选题：急性脑梗死 + 微小RNA-c　；参考：《山东医药》2016年38期

【摘要】：目的分析与急性脑梗死患者血清微小RNA-181c(miR-181c)水平与认知功能受损的关系。方法收集158例急性脑梗死患者,其中梗死后存在认知功能受损67例(受损组),认知功能正常91例(正常组)。采用实时荧光定量PCR技术检测血清miR-181c,用多元线性回归分析法分析认知功能受损发生的影响因素,以受试者工作特征曲线(ROC曲线)评估血清miR-181c预测认知功能受损的价值。结果受损组及正常组血清miR-181c相对表达量为1.57±0.19、1.32±0.15,两组比较P0.05。多元线性回归分析显示,血清miR-181c、年龄、HbA_(1c)、血Hcy、相关脑功能区梗死是急性脑梗死患者发生认知功能受损的独立影响因素(P均0.05)。ROC曲线分析显示,当血清miR-181c截断值为1.33时,其预测急性脑梗死患者发生认知功能受损的曲线下面积为0.813(95%CI:0.746~0.880),灵敏度为91.0%,特异度为58.2%。结论急性脑梗死后认知功能受损患者血清miR-181c水平升高,血清miR-181c水平升高是急性脑梗死后认知功能受损的独立危险因素和预测指标。
[Abstract]:Objective to analyze the relationship between serum minimal RNA-181cmmiR-181c and cognitive impairment in patients with acute cerebral infarction (ACI).Methods among 158 patients with acute cerebral infarction, there were 67 cases with cognitive impairment after infarction (group A) and 91 cases with normal cognitive function (n = 91).Real time fluorescence quantitative PCR was used to detect miR-181c. the influencing factors of cognitive impairment were analyzed by multivariate linear regression analysis, and the value of serum miR-181c in predicting cognitive impairment was evaluated by operating characteristic curve (ROC curve).Results the relative expression of serum miR-181c in impaired group and normal group was 1.57 卤0.191.32 卤0.15, compared with that in two groups (P0.05).Multivariate linear regression analysis showed that serum miR-181c, age of HbACTs 1c, blood Hcyand related cerebral functional area infarction were independent influencing factors of cognitive impairment in patients with acute cerebral infarction (ACI). The results of 0.05).ROC curve showed that when serum miR-181c truncation value was 1.33,The area under the curve of predicting cognitive impairment in patients with acute cerebral infarction was 0.81395% CI: 0.746 ~ 0.880%, sensitivity was 91.0, specificity was 58.2%.Conclusion Serum miR-181c level and serum miR-181c level in patients with cognitive impairment after acute cerebral infarction are independent risk factors and predictors of cognitive impairment after acute cerebral infarction.
【作者单位】：潍坊医学院附属益都中心医院;青州市人民医院;
【基金】：山东省潍坊市科技局科研课题自助项目(2015WS109)
【分类号】：R743.33

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