急性ST段抬高型心肌梗死患者骨膜蛋白水平变化的临床意义

发布时间：2018-04-19 15:28

本文选题：急性ST段抬高型心肌梗死 + 骨膜蛋白　；参考：《中国动脉硬化杂志》2016年10期

【摘要】：目的通过检测急性ST段抬高型心肌梗死(STEAMI)患者和非冠心病患者骨膜蛋白(PN)水平,探讨PN水平与STEAMI患者心功能、短期预后的关系。方法选取2014年5月至2014年9月住院并行冠状动脉介入治疗的50例STEAMI患者为观察组,非冠心病住院患者36例作为对照组。检测血浆PN水平和其他指标。观察组患者针对临床终点事件随访6个月。收集数据后进行统计学分析。结果观察组PN水平明显高于对照组(45.43±40.10 mg/L比10.25±11.64 mg/L,P0.0001)。观察组PN水平与Killip分级呈正相关(r=0.531,P0.0001),与LVEF呈负相关(r=-0.342,P0.05)。随访6个月后,观察组PN水平与不稳定型心绞痛、心力衰竭及复合临床终点事件发生率呈正相关(均P0.05)。结论 STEAMI患者高PN水平可能预示着较差的左心室收缩功能和心肌梗死后半年内更容易发生不良心血管事件。
[Abstract]:Objective to investigate the relationship between PN level and cardiac function and short-term prognosis in patients with acute ST segment elevation myocardial infarction (STEAMI) and non coronary heart disease (STEAMI). Methods 50 patients who were hospitalized with coronary intervention from May 2014 to September 2014 were selected as observation group and non coronary heart disease patients. 36 cases were used as control group. The level of plasma PN and other indexes were detected. The patients in the observation group were followed up for 6 months. The results were statistically higher than those in the control group (45.43 + 40.10 mg/L ratio 10.25 + 11.64 mg/L, P0.0001). The level of PN in the observation group was positively correlated with the Killip classification (r=0.531, P0.0001). There was a negative correlation with LVEF (r=-0.342, P0.05). After 6 months of follow-up, the PN level in the observation group was positively correlated with the incidence of unstable angina, heart failure and complex clinical endpoint events (P0.05). Conclusion the high PN level in STEAMI patients may indicate poor left ventricular systolic function and more adverse cardiac blood flow within six months after myocardial infarction. Tube event.

【作者单位】：中国医科大学附属盛京医院心内科;抚顺矿务局总医院心内科;
【分类号】：R542.22

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