急诊感染患者凝血障碍与脓毒血症的关系及参考评价

发布时间：2018-04-19 16:03

  本文选题：急诊 + 感染　； 参考：《中华医院感染学杂志》2017年23期

【摘要】：目的探讨急诊感染患者凝血障碍与脓毒血症之间的关系及其参考价值。方法选取2014年1月-2015年12月期间医院收治的128例急性感染患者作为临床研究对象,根据全身炎症反应综合征评分及序贯器官衰竭评分将患者随机分为单纯感染组46例、脓毒血症组50例、重度脓毒血症组32例,并分别对三组急诊感染患者的死亡情况、凝血指标变化情况、抗凝指标变化情况、炎症指标变化情况进行比较和分析。结果与单纯感染组病死率6.52%、脓毒血症组病死率10.00%比较,重度脓毒血症组的病死率上升为34.38%,差异有统计学意义(P0.05);与单纯感染组、脓毒血症组比较,重度脓毒血症组的血小板计数(PLT)和D-二聚体均升高,差异有统计学意义(P0.05);与单纯感染组、脓毒血症组比较,重度脓毒血症组的抗凝血酶Ⅲ抗体(AT-Ⅲ)、活化蛋白C(APC)均明显降低,差异有统计学意义(P0.05);与单纯感染组、脓毒血症组比较,重度脓毒血症组的C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)均升高,差异有统计学意义(P0.05)。结论急诊感染患者凝血障碍与脓毒血症严重程度密切相关,对凝血功能的检测必将为准确判断患者脓毒血症病情的严重程度提供具有价值的参考。
[Abstract]:Objective to study the relationship between coagulation disorder and sepsis in emergency infection patients and its reference value.Methods 128 patients with acute infection from January 2014 to December 2015 were selected as clinical study objects. According to systemic inflammatory response syndrome score and sequential organ failure score, the patients were randomly divided into simple infection group (46 cases).There were 50 cases in sepsis group and 32 cases in severe sepsis group. The death rate, coagulation index, anticoagulant index and inflammatory index were compared and analyzed in three groups.Results the fatality rate of severe sepsis group was 34.38 compared with that of simple infection group (6.52%) and sepsis group (10.00%), the difference was statistically significant (P 0.05), and that of sepsis group was higher than that of simple infection group (P 0.05), and that of sepsis group was 10.00% (P < 0.05).In severe sepsis group, the platelet count (PLT) and D-dimer increased significantly (P 0.05), compared with those in infection group and sepsis group, the levels of AT- 鈪，

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