不同胎龄围生期窒息与多器官功能损伤的相关性

发布时间：2018-04-20 04:28

本文选题：多器官功能损伤 + 围生期窒息　；参考：《山东大学学报(医学版)》2016年09期

【摘要】：目的探讨不同胎龄围生期窒息与多器官功能损伤(MODS)的相关性。方法收集山东大学附属济南市中心医院产科有窒息高危因素的新生儿165例,根据脐动脉血气分析结果及Apgar评分判断有无围生期窒息,将其分为早产窒息组、足月窒息组、早产对照组、足月对照组,比较各组MODS的发生率。165例中发生围生期窒息的新生儿有79例,根据胎龄将其分为早期早产窒息组、晚期早产窒息组、足月窒息组,比较各组窒息后MODS的严重程度;根据窒息程度分为轻度窒息组、重度窒息组,比较两组MODS的发生率及严重程度。结果早产窒息组MODS发生率高于足月儿窒息组(χ~2=5.37,P0.05)。窒息后MODS严重程度:早期早产窒息组、晚期早产窒息组、足月窒息组比较差异有统计学意义(χ~2=6.11,P0.05),胎龄与M ODS的发生率呈正相关性(r=0.29),胎龄与窒息后MODS程度呈正相关性(r=0.35);轻度窒息组与重度窒息组MODS发生率差异有统计学意义(χ~2=9.30,P0.05),轻度窒息组与重度窒息组MODS严重程度差异有统计学意义(χ~2=6.80,P0.05)。结论早产儿围生期窒息后发生MODS的风险高于足月儿;胎龄越小,窒息后MODS的发生率越高、程度越重;围生期窒息越重,MODS的发生率越高、程度越严重。
[Abstract]:Objective to investigate the relationship between perinatal asphyxia and multiple organ function injury (MODS) at different gestational ages. Methods 165 neonates with high risk factors of asphyxia were collected from Jinan Central Hospital affiliated to Shandong University. According to the results of umbilical artery blood gas analysis and Apgar score, the neonates were divided into premature asphyxia group and term asphyxia group. There were 79 cases of perinatal asphyxia in each group. According to gestational age, they were divided into early premature asphyxia group, late premature birth asphyxia group, term asphyxia group, and term asphyxia group. The severity of MODS after asphyxia was compared, and according to the degree of asphyxia, the incidence and severity of MODS were compared between mild asphyxia group and severe asphyxia group. Results the incidence of MODS in premature asphyxia group was higher than that in term asphyxia group (蠂 ~ (2) 5.37) (P0.05). MODS severity after asphyxia: early premature asphyxia group, late premature birth asphyxia group, There was a significant difference in term asphyxia group (蠂 ~ 2 / 2 ~ (6.11) P _ (0.05)), gestational age and M _ (ODS) incidence were positively correlated, gestational age had a positive correlation with MODS degree after asphyxia, and there was a significant difference between mild asphyxia group and severe asphyxia group (蠂 ~ (29.30) P _ (0.05), P < 0.05). There was significant difference in MODS severity between mild asphyxia group and severe asphyxia group. Conclusion the risk of MODS in premature infants after perinatal asphyxia is higher than that in term infants; the lower the gestational age, the higher the incidence and severity of MODS after asphyxia, and the higher the incidence and severity of mods in perinatal asphyxia.
【作者单位】：泰山医学院研究生院;山东大学附属济南市中心医院儿科;
【基金】：山东省科技发展计划(2013GSF11868)
【分类号】：R714.7;R459.7

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