丁苯酞对急性脑梗死患者认知功能和血清学指标的影响及二者相关性分析

发布时间：2018-04-22 00:16

本文选题：丁苯酞 + 急性脑梗死　；参考：《中国药房》2017年02期

【摘要】：目的:探讨丁苯酞对急性脑梗死(ACI)患者认知功能和血清学指标的影响,并分析二者的相关性。方法:将我院2014年7月-2015年5月的88例ACI患者按照随机数字表法分为对照组(n=38)和观察组(n=50)。对照组患者给予阿司匹林肠溶片100mg(首次剂量300 mg),po,qd,以及吸氧、补液等常规治疗;观察组患者在此基础上给予丁苯酞胶囊0.2 g,po,tid。两组患者均治疗1个月。观察两组患者简易精神状态检查量表(MMSE)评分和血清学指标[血清同型半胱氨酸(Hcy)、基质金属蛋白酶9(MMP-9)、6-酮-前列腺素-F1a(6-k-PGF1a)和神经元特异性烯醇化酶(NSE)],分析观察组患者治疗后MMP-9、6-k-PGF1a、NSE与MMSE总评分的相关性,并记录不良反应发生情况。结果:治疗后,观察组患者的MMSE总评分和6-k-PGF1a水平明显高于对照组,MMP-9、NSE水平明显低于对照组,差异均有统计学意义(P0.05)。观察组患者的MMP-9、NSE与MMSE总评分呈显著负相关,6-k-PGF1a与MMSE总评分呈显著正相关。观察组患者不良反应发生率(16.0%)与对照组(18.4%)比较,差异无统计学意义(P0.05)。结论:丁苯酞可明显改善ACI患者的认知功能,安全性较好;血清中MMP-9、NSE、6-k-PGF1a的表达可能与患者的认知功能损伤相关。
[Abstract]:Objective: To investigate the effect of butylphthalide on cognitive function and serological index in patients with acute cerebral infarction (ACI), and to analyze the correlation between the two cases. Methods: 88 cases of ACI patients in May of July 2014 in our hospital were divided into the control group (n=38) and the observation group (n=50) according to the random number table method. The control group was given the first dose of Aspirin Enteric-coated Tablets (the first dose). 300 mg), Po, QD, and routine treatment of oxygen inhalation and rehydration; on this basis, the patients in the observation group were treated with butylphthalide capsule 0.2 g, Po, and tid. two for 1 months. The two groups of simple mental state examination scale (MMSE) score and serological index [serum homocysteine (Hcy), matrix metalloproteinase 9 (MMP-9), 6- ketone prostaglandin) were observed. -F1a (6-k-PGF1a) and neuron specific enolase (NSE)], analyze the correlation of the total score of MMP-9,6-k-PGF1a, NSE and MMSE in the observation group after treatment, and record the occurrence of adverse reactions. Results: after treatment, the total MMSE score and 6-k-PGF1a level of the patients in the observation group were significantly higher than those of the control group, and the level of MMP-9 and NSE was significantly lower than that of the control group. The difference was significantly lower than that of the control group. There was significant statistical significance (P0.05). The total score of MMP-9, NSE and MMSE in the observation group was negatively correlated, and there was a significant positive correlation between the total score of 6-k-PGF1a and MMSE. The incidence of adverse reactions in the observation group (16%) was compared with the control group (18.4%), the difference was not statistically significant (P0.05). Conclusion: butylphthalide can improve the cognitive function of ACI patients, safety The expression of MMP-9, NSE and 6-k-PGF1a in serum may be related to cognitive impairment.

【作者单位】：天津中医药大学第一附属医院北院老年病科;天津中医药大学第一附属医院北院急诊科;
【分类号】：R743.33

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