老年急性脑梗死患者感染病原菌分布与对内皮素和脑钠肽水平的调查研究

发布时间：2018-04-25 05:39

本文选题：急性脑梗死 + 病原菌　；参考：《中华医院感染学杂志》2016年06期

【摘要】：目的分析老年急性脑梗死患者感染病原菌分布,并研究其对内皮素和脑钠肽(BNP)水平的影响,为临床相关治疗提供借鉴。方法对2010年3月-2014年8月医院诊治的80例老年急性脑梗死感染患者为感染组,同期选取老年急性脑梗死未感染患者100例为未感染组,健康体检者100名为对照组,分析病原菌分布及3组受试人员的临床指标,数据采用SPSS 19.0。结果感染组80例患者共分离出病原菌80株,以革兰阴性菌为主,共46株占57.5%;与对照组和未感染组相比,感染组患者血清中内皮素及肿瘤坏死因子α(TNFα)、转化生长因子β(TGFβ)、成纤维细胞生长因子(bFGF)、白细胞介素6-(IL-6)和白细胞介素-10(IL-10)水平明显高于其他两组,差异有统计学意义(P0.01)。结论老年急性脑梗死患者容易受到病原菌感染,病原菌以革兰阴性菌为主,且感染引起患者血清中内皮素水平升高,BNP蛋白水平明显降低。
[Abstract]:Objective to analyze the distribution of pathogenic bacteria in senile patients with acute cerebral infarction and to study its effect on the levels of endothelin and brain natriuretic peptide (BNP) in order to provide reference for clinical treatment. Methods from March 2010 to August 2014, 80 elderly patients with acute cerebral infarction (ACI) were selected as infected group, 100 elderly patients with ACI as uninfected group and 100 healthy persons as control group. The distribution of pathogenic bacteria and the clinical indexes of three groups of subjects were analyzed. The data were obtained by SPSS 19.0. Results A total of 80 strains of pathogenic bacteria were isolated from 80 patients in the infected group, 46 strains of which were mainly Gram-negative bacteria, which were compared with the control group and the uninfected group. The serum levels of endothelin, tumor necrosis factor 伪 -TNF- 伪, transforming growth factor 尾 -TGF- 尾, fibroblast growth factor (FGF- 6) and interleukin-10 (IL-10) in the infected group were significantly higher than those in the other two groups (P 0.01). Conclusion the geriatric patients with acute cerebral infarction are susceptible to the infection of pathogenic bacteria, the main pathogens are Gram-negative bacteria, and the level of endothelin in serum of patients with acute cerebral infarction is increased and the protein level of BNP is obviously decreased.
【作者单位】：丽水市人民医院急诊科;
【基金】：浙江省医药卫生科技计划基金资助项目(2012KYB213)
【分类号】：R743.33

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