血清降钙素原在诊断尿脓毒血症中的意义

发布时间：2018-04-25 17:49

  本文选题：尿脓毒血症 + 降钙素原　； 参考：《重庆医科大学学报》2014年06期

【摘要】：目的:探讨血清降钙素原(procalcitonin,PCT)在诊断尿脓毒血症中的临床意义。方法:41例尿脓毒血症患者为尿脓毒血症组,79例普通泌尿道感染患者对照组,检测2组患者PCT、超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、白细胞(white blood cells,WBC)及中性粒细胞水平;绘制受试者工作特征(receiver operating characteristic,ROC)曲线,评价PCT及相关炎症指标鉴别尿脓毒血症高危患者的能力,并对PCT与hs-CRP、WBC及中性粒细胞进行双变量相关性分析。结果:与对照组比较,尿脓毒症组PCT浓度(μg/L)、hs-CRP(mg/L)、WBC(×109个/L)及中性粒细胞(×109个/L)均明显增高(PCT浓度:3.113±1.953 vs.0.057±0.0550;hs-CRP:18.820±15.460 vs.7.440±14.520;WBC:12.860±4.002 vs.8.150±4.630;中性粒细胞:90.335±3.975 vs.74.30±15.40),差异均有统计学意义(P0.05)。ROC曲线分析显示,PCT的曲线下面积(area under the curve,AUC)为1,高于hs-CRP、WBC、中性粒细胞(AUC分别为0.813、0.875、0.984);且PCT为2.000μg/L时,敏感性为90.2%,特异性为100%,优于其他传统炎症指标。双变量相关性分析显示,PCT与WBC和中性粒细胞数均呈显著正相关,分别为(rs=0.609,P=0.000;rs=0.057,P=0.000),而与hs-CRP有相关性(rs=0.213,P=0.020)。结论:PCT在诊断尿脓毒血症具有较高的敏感度和特异度,有助于尿脓毒血症的早期诊断及早期治疗。
[Abstract]:Objective: to investigate the clinical significance of serum procalcitonin (PCT) in the diagnosis of urinary sepsis. Methods 41 patients with urosepsis were divided into two groups: urosepsis group (n = 79) and urinary tract infection group (n = 79). The levels of PCT, hypersensitive C-reactive protein hs-CRP, white blood cells and neutrophils in two groups were detected. The receiver operating characteristic curve was drawn to evaluate the ability of PCT and related inflammatory indexes to distinguish high risk patients with urinary sepsis, and the correlation between PCT and hs-CRP WBC and neutrophils was analyzed. Results: compared with the control group, 灏胯創姣掔棁缁凱CT娴撳害(渭g/L),hs-CRP(mg/L),WBC(脳109涓，

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