脓毒症治疗新策略:免疫调理研究新认识

发布时间：2018-04-26 00:02

本文选题：脓毒症 + 免疫抑制　；参考：《医学与哲学(B)》2017年02期

【摘要】：脓毒症的发病率不断攀升,病死率仍然居高不下。研究发现,脓毒症的病理生理机制十分复杂。随着疾病进展,机体免疫系统调节机制失衡,易于出现免疫抑制状态。这是造成患者二次机会感染以及死亡的重要原因。近年来,人们日益重视针对机体紊乱状态的免疫调理治疗,开展了以各类免疫细胞为调节靶点的基础和临床研究。多种重组细胞因子、抗体及制剂等表现出良好的生物学活性,部分药物现已经进入临床试验阶段,并且在改善脓毒症患者免疫状态等方面取得初步疗效。因此,免疫调理治疗具有重要研究前景和临床意义。
[Abstract]:The incidence of sepsis is rising and the mortality remains high. The pathophysiological mechanism of sepsis is very complicated. With the progress of the disease, the immune regulation mechanism of the body is out of balance and prone to immunosuppression. This is an important cause of secondary opportunistic infection and death. In recent years, more and more attention has been paid to the immune conditioning therapy for the disorder of the body, and the basic and clinical studies have been carried out with all kinds of immune cells as the regulatory targets. A variety of recombinant cytokines, antibodies and preparations have shown good biological activities, some drugs have entered the clinical trial stage, and in improving the immune status of patients with sepsis and other aspects of the preliminary curative effect. Therefore, immune conditioning therapy has an important research prospect and clinical significance.
【作者单位】：解放军总医院第一附属医院创伤研究中心;首都医科大学附属北京朝阳医院急诊科;
【基金】：国家自然科学基金资助项目(81501698,81372054,81130035) 国家重点基础研究发展计划项目(2012CB518102)
【分类号】：R459.7

【相似文献】