急性脑梗死患者血清HSP70水平变化及意义

发布时间：2018-04-26 01:11

本文选题：热休克蛋白 + 急性脑梗死　；参考：《山东医药》2016年11期

【摘要】：目的观察急性脑梗死患者血清热休克蛋白70(HSP70)水平变化,并探讨其意义。方法将61例急性脑梗死患者作为观察组,30例健康者作为对照组,采用酶联免疫吸附法检测观察组发病后第1~3天、第7、14、28天及对照组血清HSP70,采用Spearman秩相关检验分析观察组血清HSP70水平与NIHSS评分、脑梗死体积、Barthel指数评定量表评分的关系。结果与对照组相比,观察组血清HSP70水平在发病后第1~3天、第7、14、28天均高(P均0.05)。观察组发病后第1~3天、第7、14和28天血清HSP70水平与NIHSS评分均呈正相关(r分别为0.365、0.628、0.371、0.608,P均0.05),与脑梗死体积均呈正相关(r分别为0.402、0.437、0.411、0.398,P均0.05)。观察组发病后第7、28天血清HSP70水平与BI评分呈负相关(r分别为-0.349、-0.621,P均0.05)。以6.33 ng/m L为界值,血清HSP70诊断急性脑梗死的灵敏度为73.3%,特异度为96.7%,ROC曲线下面积为0.943 3(P0.000 1)。结论急性脑梗死患者血清HSP70水平升高,监测血清HSP70水平有助于判断急性脑梗死病情严重程度和预后。
[Abstract]:Objective to observe the changes of serum heat shock protein 70 (HSP70) in patients with acute cerebral infarction (ACI) and to explore its significance. Methods Sixty-one patients with acute cerebral infarction were used as control group and 30 healthy subjects as control group. Elisa was used to detect the first three days after the onset of cerebral infarction in the observation group. Serum HSP70 was analyzed by Spearman rank correlation test on the 28th day of the 7th day and the control group. The relationship between the serum HSP70 level and the NIHSS score and the assessment scale of the cerebral infarction volume and the Barthel index were analyzed by Spearman rank correlation test. Results compared with the control group, the serum HSP70 levels in the observation group were significantly higher than those in the control group on the 1st day, the 3rd day and the 7th day, 14th day, respectively. In the observation group, the serum HSP70 level was positively correlated with the NIHSS score on the 3rd day, the 7th day and the 28th day after the onset of the disease. The positive correlation r was 0.365 卤0.628 卤0.371U 0.608P, and the positive correlation with the volume of cerebral infarction was 0.402 卤0.4370.4370.398P respectively. There was a negative correlation between the serum HSP70 level and BI score in the observation group on the 7th day after the onset of the disease, and the r values were -0.349 ~ -0.621 (P < 0.05). With 6.33 ng/m L as the threshold, the sensitivity of serum HSP70 in the diagnosis of acute cerebral infarction was 73.3, and the specificity was 96.70.The area under the ROC curve was 0.943 3(P0.000 1. Conclusion the level of serum HSP70 is higher in patients with acute cerebral infarction. Monitoring the level of serum HSP70 is helpful to judge the severity and prognosis of acute cerebral infarction.
【作者单位】：绵阳市中心医院;
【基金】：四川省卫生厅科研课题(130443,130446)
【分类号】：R743.33

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