重组人脑利钠肽对于急性心肌梗死后老年心力衰竭患者疗效及预后的影响

发布时间：2018-04-26 13:41

本文选题：重组人脑利钠肽 + 急性心肌梗死　；参考：《中国老年学杂志》2016年03期

【摘要】：目的分析重组人脑利钠肽(rh-BNP)治疗急性心肌梗死(AMI)后心力衰竭老年患者的临床疗效及对预后的影响。方法采用随机数字表法将115例AMI后心力衰竭患者分为试验组58例和对照组57例,两组均给予利尿、扩血管、纠正心衰、吸氧、抗凝等常规治疗,试验组加用静脉注射rh-BNP。结果试验组治疗后血浆超敏C-反应蛋白(hs-CRP)、脑钠肽(BNP)、B型脑钠肽前体(NT-pro BNP)显著低于对照组(P0.05)。治疗后试验组左室射血分数(LVEF)〔(51.3±3.6)%〕显著高于对照组〔(48.8±4.0)%〕(P0.05),试验组左室收缩末期容积(LVESV)〔(66.2±5.9)ml〕、左室舒张末期容积(LVEDV)〔(117.6±6.1)ml〕显著低于对照组(P0.05)。试验组治疗后6个月的心血管不良事件发生率(8.62%)显著低于对照组(21.05%)(P0.05)。试验组治疗后1年的死亡率(0.00%)显著低于对照组(7.41%)(P0.05)。结论 rh-BNP治疗对AMI后心力衰竭患者具有恢复患者心功能、改善内分泌指标的积极作用。
[Abstract]:Objective to evaluate the clinical efficacy and prognosis of recombinant human brain natriuretic peptide rh-BNPs in elderly patients with heart failure after acute myocardial infarction (AMI). Methods one hundred and five patients with heart failure after AMI were randomly divided into two groups: experimental group (n = 58) and control group (n = 57). Both groups were given diuretic, vasodilator, heart failure correction, oxygen inhalation and anticoagulant therapy. Results after treatment, plasma hypersensitive C-reactive protein (hs-CRPN) and brain natriuretic peptide (BNPB) precursor, NT-pro BNPP, were significantly lower in the experimental group than those in the control group (P 0.05). After treatment, the left ventricular ejection fraction (LVEF) in the trial group (51.3 卤3.6) was significantly higher than that in the control group (48.8 卤4.0). The left ventricular end-systolic volume (LVESVV) and left ventricular end-diastolic volume (LVEDVV) were significantly lower in the trial group than in the control group. The incidence of cardiovascular adverse events in the trial group was significantly lower than that in the control group at 6 months after treatment (P = 8.62) and was significantly lower than that in the control group (P = 21.05). One year after treatment, the mortality rate in the trial group was significantly lower than that in the control group (7.41%). Conclusion rh-BNP therapy has a positive effect on the recovery of cardiac function and the improvement of endocrine index in patients with heart failure after AMI.
【作者单位】：阜阳市人民医院心血管内科;
【基金】：安徽省卫生厅科技计划项目(No.014kbp328)
【分类号】：R542.22;R541.6

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