重症急性胰腺炎全肠外营养和肠内营养疗效的Meta分析

发布时间：2018-04-30 12:32

本文选题：重症急性胰腺炎 + 全胃肠外营养　；参考：《山西医科大学》2014年硕士论文

【摘要】：目的：系统评价肠内营养（EN）和全胃肠外营养（TPN）对重症急性胰腺炎（SAP）患者的疗效，对有关文献进行荟萃分析。方法：检索中国期刊网全文数据库、维普数据库、万方数据库、pubmed数据库有关EN和TPN治疗SAP的临床随机对照试验。检索年限自2005年1月至2013年12月。利用Review Manager5.0.18系统进行统计分析，绘制出森林图与漏斗图；采用Stata12.0对漏斗图不对称性进行检验。结果：EN与TPN进行比较，前者能显著性降低器官衰竭率（=0.33，95%:0.18~0.63，=0.0007）、手术干预率（=0.24，95%:0.14~0.42，＜0.00001）、感染率（=0.26，95%:0.18~0.37，＜0.00001）、死亡率（=0.31，95%:0.19~0.51，＜0.00001）。结论：在SAP的治疗中，EN效果优于TPN，能显著降低SAP患者的感染率、器官衰竭率、手术干预率及死亡率。
[Abstract]:Objective: to evaluate the efficacy of enteral nutrition (en) and total parenteral nutrition (TPN) in patients with severe acute pancreatitis (SAP). Methods: a randomized controlled clinical trial of en and TPN on SAP was conducted by searching the full text database, Weip database and Wanfang database of Chinese Journal Network. The retrieval period is from January 2005 to December 2013. The forest map and funnel map are drawn by using Review Manager5.0.18 system, and the asymmetry of funnel graph is tested by Stata12.0. Results compared with TPN, the former significantly reduced the rate of organ failure (0.395%), and the rate of surgical intervention was 0.24 95: 0.140.42, < 0.00001, the infection rate was 0.260.95: 0.180.37, and the mortality rate was 0.31: 95: 0.190.190.1. Conclusion: in the treatment of SAP, the effect of en is better than that of SAP, and it can significantly reduce the infection rate, the rate of organ failure, the rate of operation intervention and the death rate of SAP patients.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R657.51

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