氨甲环酸对创伤性凝血病患者的疗效及作用机制

发布时间：2018-05-03 08:12

本文选题：氨甲环酸 + 创伤性凝血病　；参考：《中国现代医学杂志》2017年24期

【摘要】：目的探讨氨甲环酸对创伤性凝血病患者的临床疗效及作用机制。方法选取2015年4月-2016年6月就诊于该院的创伤性凝血病患者106例,根据随机数表法原则将所有患者分为两组,各53例。对照组采用常规疗法,如手术止血、输注血制品及补充钙质。观察组在此基础上加用氨甲环酸治疗。比较两组治疗指标、炎症因子水平、血制品输注量及预后。结果观察组凝血酶原时间(PT)、活化部分凝血或酶时间(APTT)及纤维蛋白原(Fbg)等指标改善情况优于对照组,差异有统计学意义(P0.05);观察组肿瘤坏死因子α(TNF-α)等炎症因子水平低于对照组,差异有统计学意义(P0.05);观察组血制品输用量少于对照组,差异有统计学意义(P0.05);观察组预后情况优于对照组,差异有统计学意义(P0.05)。结论氨甲环酸治疗创伤性凝血病效果显著,能够减少出血量,改善患者凝血功能,降低炎症反应,有助于改善预后。
[Abstract]:Objective to investigate the clinical effect and mechanism of methacylic acid in patients with traumatic coagulation disease. Methods 106 patients with traumatic coagulation were selected from April 2015 to June 2016. According to the principle of random number table, all patients were divided into two groups, 53 cases in each group. The control group was treated with routine therapy, such as surgical hemostasis, transfusion of blood products and calcium supplement. On this basis, the observation group was treated with methachloroic acid. The treatment index, inflammatory factor level, blood product infusion volume and prognosis were compared between the two groups. Results the changes of prothrombin time (PTT), activated partial coagulation (APTT) and fibrinogen (Fbg) in the observation group were better than those in the control group (P 0.05), and the levels of inflammatory factors such as tumor necrosis factor 伪 (TNF- 伪) in the observation group were lower than those in the control group. The difference was statistically significant (P 0.05); the dosage of blood products in the observation group was less than that in the control group (P 0.05); the prognosis of the observation group was better than that in the control group (P 0.05). Conclusion the treatment of traumatic thromboplasmosis with carbamoic acid is effective, which can reduce the amount of blood loss, improve the blood coagulation function, reduce the inflammatory reaction, and improve the prognosis.
【作者单位】：河北省石家庄市第三医院急诊科;
【基金】：石家庄市科学技术研究与发展指导计划(No:151460773)
【分类号】：R641

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