甲状旁腺激素联合检测在急性心力衰竭诊断中的价值研究

发布时间：2018-05-08 18:40

  本文选题：甲状旁腺激素 + N端B型-脑利钠肽前体　； 参考：《医学与哲学(B)》2017年07期

【摘要】：本文选取了2016年4月~2017年2月于海口市人民医院急诊和门诊首诊的急性心力衰竭组100例,和健康查体中心健康组100例,分别符合纳入标准进行分组比较。心力衰竭临床诊断标准符合《2016年欧洲心脏病学会急性心力衰竭指南》。进行ELISA法检测两组血清PTH、NT-pro BNP,分别检测和联合检测两组的血清PTH和NT-proBNP。同时超声心动监测心脏血流动力学指标,再以不同左心室射血分数下分组,分别统计单独检测血清PTH和NT-proBNP和联合检测两者的敏感度、特异度。结果显示:单独检测血清PTH和NT-proBNP,急性心力衰竭组与健康组比较,统计有差异(P0.05)。分别比较两组的联合检测血清PTH和NT-proBNP,急性心力衰竭组在左心室射血分数LVEF≥50%时既表现出统计学差异(P0.05),且敏感度和特异度高。以上说明血清PTH和NT-proBNP联合检测提高心衰实验室检查敏感性,并结合超声血流动力学指标可提高早期未出现血流动力学障碍时急性心力衰竭诊断准确性。可有效判读临床结果并便于急诊分级系统管理,尤其是社区门诊监测中射血分数尚在代偿范围的心力衰竭患者,降低心力衰竭患者的漏诊和误诊。从心功能和体内电解质代谢角度及早进行多维度整体判断心力衰竭患者病理生理变化,具有一定的临床应用价值。
[Abstract]:From April 2016 to February 2017, 100 patients with acute heart failure and 100 healthy people in the health examination center were selected from the emergency department and outpatient clinic of Haikou people's Hospital. The patients were divided into two groups according to the inclusion criteria. The clinical diagnostic criteria for heart failure are in accordance with the European Heart Association guidelines for Acute Heart failure 2016. The serum PTH and NT-proBNPs of the two groups were detected by ELISA assay. At the same time, the cardiac hemodynamic parameters were monitored by echocardiography. The sensitivity and specificity of serum PTH and NT-proBNP were measured separately and combined with different left ventricular ejection fractions (LVEF). The results showed that serum PTH and NT-proBNPs were detected separately, and there was a statistical difference between the acute heart failure group and the healthy group (P 0.05). Serum PTH and NT-proBNPs were compared between the two groups. The acute heart failure group showed significant difference in left ventricular ejection fraction (LVEF) 鈮，

本文编号：1862567