不同潮气量机械通气对大鼠膈肌放电的影响

发布时间：2018-05-13 13:47

本文选题：机械通气 + 膈肌放电　；参考：《中国呼吸与危重监护杂志》2016年06期

【摘要】：目的探讨不同潮气量机械通气对大鼠膈肌放电的影响。方法将24只SD大鼠随机分为大潮气量组(10 m L/kg)、小潮气量组(5 m L/kg)和对照组。大潮气量组和小潮气量组大鼠进行不同潮气量的容量控制通气4 h,对照组麻醉后进行自主呼吸。在0、2、4 h分别测定大鼠膈肌放电情况,并监测血压、经皮血氧饱和度(Sp O_2)及呼气末二氧化碳分压(Pet CO_2),分析大鼠膈肌放电在不同潮气量和通气时长下的变化趋势以及Sp O_2、Pet CO_2与膈肌放电之间的关系。结果与对照组比较,大潮气量组膈肌放电频率降低,膈肌放电面积增大,膈肌放电振幅×膈肌放电频率(A×R)差异无统计学意义;而小潮气量组膈肌放电频率及膈肌放电面积无显著差异,仅膈肌放电振幅×膈肌放电频率(A×R)明显升高。Sp O_2在对照组及大潮气量组有所下降,Pet CO_2在大潮气量组也有所下降,其余各指标没有显著变化。结论不同潮气量机械通气对大鼠膈肌放电的影响不同,小潮气量机械通气可以兴奋呼吸中枢,增强膈肌放电,而大潮气量则表现为抑制效应。
[Abstract]:Objective to investigate the effect of different tidal volume mechanical ventilation on diaphragm discharges in rats. Methods Twenty-four Sprague-Dawley rats were randomly divided into two groups: the high tide volume group (10 mL / kg), the small tidal volume group (5 mL / kg) and the control group. The rats in the high tide volume group and the small tidal volume group were ventilated with different tidal volume for 4 h, and the control group was anesthetized to breathe autonomously. The diaphragm discharges in rats were measured at 0 ~ 2 h and blood pressure was monitored. Percutaneous oxygen saturation (SPO _ 2) and end-expiratory partial pressure of carbon dioxide (Pet CO2C) were used to analyze the changes of diaphragm discharges in rats under different tidal volume and duration of ventilation, and the relationship between spp _ O _ 2Pet CO_2 and diaphragm discharge. Results compared with the control group, the frequency of diaphragm discharge decreased and the area of diaphragm discharge increased. There was no significant difference in amplitude of diaphragm discharge 脳 frequency of diaphragm discharge. However, there was no significant difference in diaphragm discharge frequency and diaphragm discharge area in small tidal volume group, except that the amplitude of diaphragm discharge 脳 diaphragm discharge frequency (A 脳 R) increased significantly. There was no significant change in the remaining indicators. Conclusion the effects of different tidal volume mechanical ventilation on diaphragm discharges in rats are different. Small tidal volume mechanical ventilation can excite the respiratory center and enhance the diaphragm discharges, while the high tide volume is an inhibitory effect.
【作者单位】：北京大学第一医院呼吸和危重症医学科;
【基金】：国家自然科学基金(编号:81370106) 北京市自然科学基金(编号:7132187)
【分类号】：R459.7

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