胃肠道感染脓毒性休克患者临床治疗效果分析

发布时间：2018-05-15 12:08

本文选题：胃肠道感染 + 脓毒性休克　；参考：《中华医院感染学杂志》2016年06期

【摘要】：目的探讨胃肠道感染引发的脓毒性休克患者的临床治疗方案,分析其临床疗效,为临床治疗提供依据。方法分析2012年1月-2015年6月医院收治的48例胃肠道感染脓毒性休克患者临床资料,随机分为观察组和对照组各24例,观察组给予多巴胺联合去甲肾上腺素,对照组患者给予去甲肾上腺素治疗,观察两组患者治疗后血流动力学指标和氧合指标等,分析两组患者临床疗效。结果两组患者平均动脉压差异无统计学意义;观察组患者心率显著低于对照组,观察组肺动脉楔压、心排指数、体循环阻力指数和左室每搏功指数均显著高于对照组,组间差异有统计学意义(P0.05);观察组患者氧耗量显著低于对照组,氧摄取率显著较高(P0.05);观察组和对照组乳酸水平分别为(3.69±1.96)mmol/L、(4.58±2.52)mmol/L,联合使用去甲肾上腺素和多巴胺可有效降低患者乳酸水平。结论联合使用去甲肾上腺素和多巴胺可有效改善脓毒性休克症状,临床可推广使用。
[Abstract]:Objective to investigate the clinical treatment of septic shock caused by gastrointestinal tract infection and to analyze its clinical efficacy. Methods from January 2012 to June 2015, 48 patients with septic shock of gastrointestinal infection were randomly divided into two groups: the observation group (n = 24) and the control group (n = 24). The observation group was treated with dopamine combined with norepinephrine. The patients in the control group were treated with norepinephrine, the hemodynamic and oxygenation indexes were observed after treatment, and the clinical efficacy of the two groups was analyzed. Results there was no significant difference in mean arterial pressure between the two groups, the heart rate in the observation group was significantly lower than that in the control group, and the pulmonary artery wedge pressure, cardiac output index, systemic resistance index and left ventricular stroke work index in the observation group were significantly higher than those in the control group. The oxygen consumption in the observation group was significantly lower than that in the control group, and the oxygen uptake rate was significantly higher in the observation group than in the control group, and the lactate levels in the observation group and the control group were 3.69 卤1.96 mmol / L and 4.58 卤2.52 mmol / L, respectively. The combined use of norepinephrine and dopamine could effectively reduce the lactate level of the patients. Conclusion combined use of norepinephrine and dopamine can effectively improve the symptoms of septic shock.
【作者单位】：淄博市第一医院普外科;淄博市第一医院儿童保健科;山东中医药高等专科学校临床教研室;
【基金】：山东省优秀中青年科学家科研基金资助项目(2014BSE27093)
【分类号】：R459.7

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