急性脑梗死尼莫地平治疗后患者认知功能及血清HSP70水平变化

发布时间：2018-05-15 12:13

本文选题：脑梗死 + 尼莫地平　；参考：《山东医药》2016年03期

【摘要】：目的观察急性脑梗死尼莫地平治疗后患者认知功能及血清热休克蛋白70(HSP70)水平的变化,探讨尼莫地平改善血管性认知功能损害的作用机制。方法 79例急性脑梗死患者,随机分为治疗组(44例)和常规组(35例)。常规组患者急性期给予阿司匹林肠溶片(100 mg,1次/d)、血栓通(150 mg,1次/d)治疗,恢复期给予阿司匹林肠溶片(100 mg,1次/d)、阿托伐他汀片(20 mg,每晚1次)治疗;治疗组在常规组的基础上急性期给予尼莫地平片30 mg/次,3次/d,共3个月。观察两组治疗前后简明精神状态量表(MMSE)评分、北京版蒙特利尔认知评估量表(Mo CA)评分及血清HSP70水平。结果两组治疗后MMSE评分、Mo CA评分均较治疗前下降(P均0.01),但治疗组治疗后MMSE评分、Mo CA评分较常规组高(P均0.01)。常规组治疗后血清HSP70水平较治疗前下降(P0.01),治疗组治疗后血清HSP70水平较治疗前升高(P0.01)。患者血清HSP70水平和Mo CA评分、MMSE评分呈正相关(r分别为0.72、0.68,P均0.01)。结论急性脑梗死尼莫地平治疗后患者认知功能损害程度减轻,血清HSP70水平升高。
[Abstract]:Objective to observe the changes of cognitive function and serum heat shock protein 70 (HSP70) level in patients with acute cerebral infarction after nimodipine treatment, and to explore the mechanism of nimodipine in improving vascular cognitive impairment. Methods 79 patients with acute cerebral infarction were randomly divided into treatment group (n = 44) and routine group (n = 35). Patients in the routine group were treated with 100 mg / d aspirin enteric-coated tablets and 150 mg / d of Xueshuantong tablets in the acute phase, 100 mg / d of aspirin enteric-coated tablets and 20 mg / d of Atto vastatin tablets respectively in the convalescent stage. The treatment group was treated with nimodipine for 30 mg/ d for 3 months. Before and after treatment, the scores of brief mental state scale (MMSE), Beijing Montreal Cognitive Assessment scale (MMSE), and serum HSP70 level were observed. Results after treatment, the MMSE score and Mo CA score in both groups were lower than those before treatment (P < 0.01), but the MMSE score and Mo CA score in the treatment group were higher than those in the control group (P < 0.01). The level of serum HSP70 in the routine group was lower than that before treatment (P 0.01), and the level of serum HSP70 in the treatment group was higher than that before treatment (P 0.01). The positive correlation between serum HSP70 level and Mo CA score was 0.72 卤0.68 (P < 0.01). Conclusion the cognitive impairment and serum HSP70 level in patients with acute cerebral infarction after nimodipine therapy were alleviated.
【作者单位】：南京中医药大学附属张家港市中医医院;
【基金】：张家港市社会发展项目(ZKS1007)
【分类号】：R743.33

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