早期集束化治疗对感染性休克患者预后的影响

发布时间：2018-05-17 06:02

  本文选题：感染性休克 + 早期集束化治疗　； 参考：《广东医学》2017年18期

【摘要】：目的观察感染性休克患者采取早期集束化治疗的临床效果。方法将连续入组的80例感染性休克患者随机分为早期集束化治疗组(40例)和传统治疗组(40例)。记录两组患者入院时急性生理和慢性健康评分(APACHEⅡ),观察两组患者复苏终点、器官功能变化、生存时间、病死率。结果最初治疗6h时,传统治疗组患者平均动脉压(MAP)明显低于早期集束化治疗组(P0.001);传统治疗组的患者中心静脉血氧饱和度(Scv O2)、MAP显著低于早期集束化治疗组(P0.001)。治疗后72 h时传统治疗组患者的APACHEⅡ评分及多器官功能衰竭(MODS)明显高于早期集束化治疗组(P0.001)。传统治疗组总的病死率明显高于早期集束化治疗组(P=0.025),两组生存曲线分析显示,早期集束化治疗组患者平均生存时间(133.66±26.77)d,95%可信区间(95%CI)为27.824~58.176;传统治疗组平均生存时间(31.334±2.376)d,95%CI:24.619~3 1.381;随时间的延长,两组生存率逐渐下降,但传统治疗组患者生存率明显低于早期集束化治疗组。结论早期集束化治疗可以减少感染性休克患者多脏器功能衰竭发生率,降低病死率。
[Abstract]:Objective to observe the clinical effect of early cluster therapy in patients with septic shock. Methods 80 consecutive septic shock patients were randomly divided into early cluster therapy group (n = 40) and traditional treatment group (n = 40). The acute physiological and chronic health scores of the two groups were recorded. The end point of resuscitation, organ function, survival time and mortality were observed. Results at the beginning of 6 h treatment, the mean arterial pressure (MAPP) in the traditional treatment group was significantly lower than that in the early cluster therapy group (P 0.001), and the central venous oxygen saturation (scvO _ 2) map in the traditional treatment group was significantly lower than that in the early cluster therapy group (P 0.001). At 72 hours after treatment, the scores of APACHE 鈪，

本文编号：1900207