呋塞米联合多巴胺微量泵泵入对重症烧伤患者肾功能保护作用的临床观察

发布时间：2018-05-18 17:56

本文选题：呋塞米 + 多巴胺　；参考：《宁夏医科大学》2013年硕士论文

【摘要】：目的：探讨呋塞米与多巴胺联合微量泵持续泵入对于重度烧伤后肾功能保护作用方面的治疗效果。方法：选择宁夏医科大学2004年——2010年烧伤面积超过50%的重症烧伤患者60例，年龄18-60岁之间，，分为治疗组与对照组，治疗组应用速尿联合多巴胺持续微量泵泵注，对照组单独使用呋塞米，比较并观察两组治疗后12小时内平均每小时尿量及治疗后第1、3天24小时尿量，两组治疗前以及治疗后第1天、3天的血尿素氮（BUN）、血肌酐（Cr）变化，治疗3天后肾衰比率、死亡率。结果：治疗组治疗后12h内平均每小时尿量及治疗后第1、3天24h尿量明显多于对照组（p0.05）,差别有统计学意义。两组治疗前血尿素氮（BUN）、血肌酐（Cr）差异无统计学意义，治疗后第1、3天血肌酐（Cr）差别有统计学意义，血尿素氮差别无统计学意义，治疗组肾衰比例与对照组比较差别有统计学意义，死亡率比较差别无统计学意义。结论：呋塞米联合多巴胺微量泵泵注可有效平稳提高重症烧伤患者尿量，对于改善肾功能，预防肾功能衰竭有一定作用，但对于死亡率无明显影响。
[Abstract]:Objective: to investigate the effect of continuous pump infusion of furosemide and dopamine on renal function protection after severe burn. Methods: 60 severe burn patients aged 18-60 years from 2004 to 2010 in Ningxia Medical University were divided into treatment group and control group. The treatment group was treated with furosemide combined with continuous micropump injection of dopamine. The control group was treated with furosemide alone. The mean urine volume per hour within 12 hours after treatment and 24 hours after treatment were compared and observed. The changes of blood urea nitrogen bun and creatinine (Cr) in the two groups before and after treatment were compared and observed. The rate of renal failure and mortality were 3 days after treatment. Results: the average urine volume per hour in the treatment group was significantly higher than that in the control group within 12 hours and the 24h urine volume at the 1st day after treatment was significantly higher than that in the control group (P 0.05). There was no significant difference in blood urea nitrogen bun and creatinine Cr between the two groups before treatment, but there was significant difference in serum creatinine Cr on the 1st day after treatment, but there was no significant difference in blood urea nitrogen. The ratio of renal failure in the treatment group was significantly different from that in the control group. There was no significant difference in mortality. Conclusion: furosemide combined with dopamine micropump can increase urine volume of patients with severe burn effectively, improve renal function and prevent renal failure, but has no effect on mortality.
【学位授予单位】：宁夏医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R644

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