多发伤合并肺部感染患者血清及痰液细胞因子的变化观察

发布时间：2018-05-31 11:23

  本文选题：多发伤 + 肺部感染　； 参考：《中华医院感染学杂志》2017年02期

【摘要】：目的观察多发伤合并肺部感染患者血清及痰液细胞因子的变化情况,为多发伤患者肺部感染的诊断与控制提供依据。方法选取2013年6月-2016年6月医院EICU、急诊创伤病房、急诊留观病房进行治疗的46例多发伤合并肺部感染患者为A组,同时期的46例多发伤患者为B组,46名健康人员为C组,然后将三组研究对象的血清及痰液细胞因子进行检测及比较,并比较A组不同肺部感染程度患者的血清及痰液细胞因子水平。结果 A组血清及痰液细胞因子IL-4、IL-8、IL-16、TNF-α、IFN-γ水平分别为(2.46±0.19)ng/ml、(11.98±1.41)pg/ml、(45.29±4.33)ng/L、(2.37±0.26)ng/ml、(71.89±6.02)pg/ml及(3.36±0.29)ng/ml、(14.65±1.79)pg/ml、(51.80±4.62)ng/L、(3.31±0.40)ng/ml、(79.96±6.93)pg/ml,均高于B组及C组的检测水平,B组的检测水平则高于C组,且A组肺部感染较重者的检测水平高于感染较轻者,差异均有统计学意义(P0.05)。结论多发伤合并肺部感染患者血清及痰液细胞因子呈现高表达状态,且肺部感染程度对其表达水平的影响较大。
[Abstract]:Objective to observe the changes of serum and sputum cytokines in patients with multiple trauma complicated with pulmonary infection and to provide evidence for the diagnosis and control of pulmonary infection. Methods from June 2013 to June 2016, 46 patients with multiple injuries complicated with pulmonary infection in EICU, emergency trauma ward and emergency observation ward were selected as group A, and 46 patients with multiple injury in the same period as group B and 46 healthy persons as group C. Then the cytokines in serum and sputum were detected and compared among the three groups, and the levels of cytokines in serum and sputum of patients with different degree of pulmonary infection in group A were compared. 缁撴灉 A缁勮��娓呭強鐥版恫缁嗚優鍥犲瓙IL-4,IL-8,IL-16,TNF-伪,IFN-纬姘村钩鍒嗗埆涓，

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