血清生长分化因子-15与急性心肌梗死后左室重构程度的相关性研究

发布时间：2018-06-01 14:28

本文选题：血清生长分化因子-15 + 急性心肌梗死　；参考：《山西医科大学》2013年硕士论文

【摘要】：目的观察急性心肌梗死患者及正常人血清生长分化因子-15(GDF-15)水平的变化及其与心肌梗死后左房前后径、左室舒张末径、左室质量指数、左室相对室壁厚度、射血分数的相关性,探讨GDF-15与急性心肌梗死后左室重构程度的相关性。方法选取急性心肌梗死患者50例分为两组,左心室重构组30例,无左心室重构组20例。正常对照组30例。采集外周静脉血,采用酶联免疫吸附法检测血清中GDF-15水平。超声心动图测定左房前后径、左室舒张末径、舒张末左室后壁厚度、舒张末室间隔厚度,射血分数等左室重构指标。结果1.左心室重构组GDF-15的表达水平和无左心室重构组的GDF-15浓度均高于正常对照组(P0.01)。左心室重构组的GDF-15浓度高于无左心室重构组(P0.01)。 2.GDF-15浓度与年龄、性别、体重、高血压病、高血脂、糖尿病、吸烟、饮酒、高密度脂蛋白、低密度脂蛋白、甘油三酯、高敏C反应蛋白均不相关,与总胆固醇呈负相关(P=0.04),与脑钠肽呈正相关(P0.01)。 3.GDF-15与左房前后径(r=0.745,P0.01)、左室舒张末径(r=0.84,P0.01)、左室质量指数(r=0.993,P0.01)呈正相关；与射血分数(r=-0.65,P0.01)、相对室壁厚度(r=-0.96,P0.01)呈负相关。 4.采取多元线性回归分析,控制了年龄、性别和心血管危险因素后,GDF-15水平与左室质量指数呈正相关(B=0.91,P0.01)。结论GDF-15在急性心肌梗死的心肌细胞中高度表达,参与急性心肌梗死后左室重构的过程,其水平与左室重构程度呈显著的、独立的相关性。
[Abstract]:Objective to observe the changes of serum GDF-15 levels in patients with acute myocardial infarction (AMI) and normal subjects and their correlation with left atrial diameter, left ventricular end-diastolic diameter, left ventricular mass index, left ventricular relative wall thickness and ejection fraction. To investigate the correlation between GDF-15 and left ventricular remodeling after acute myocardial infarction. Methods Fifty patients with acute myocardial infarction were divided into two groups: the left ventricular remodeling group (30 cases) and the non-left ventricular remodeling group (20 cases). 30 cases in normal control group. Peripheral venous blood was collected and serum GDF-15 level was detected by enzyme linked immunosorbent assay (Elisa). Left ventricular remodeling indexes such as left atrial anteroposterior diameter left ventricular end-diastolic diameter left ventricular posterior wall thickness end-diastolic septal thickness ejection fraction and so on were measured by echocardiography. Result 1. The expression of GDF-15 in the left ventricular remodeling group and the GDF-15 concentration in the group without left ventricular remodeling were higher than those in the normal control group (P 0.01). The concentration of GDF-15 in the left ventricular remodeling group was higher than that in the no left ventricular remodeling group (P 0.01). 2.GDF-15 concentrations were not associated with age, sex, body weight, hypertension, hyperlipidemia, diabetes, smoking, alcohol consumption, HDL, LDL, triglyceride, Gao Min C-reactive protein. There was a negative correlation with total cholesterol and a positive correlation with brain natriuretic peptide (BNP). There was a positive correlation between 3.GDF-15 and left atrial anterior diameter (RV), left ventricular end-diastolic diameter (LVDD), left ventricular mass index (LVMI) and left ventricular mass index (LVMI), and a negative correlation was found between 3.GDF-15 and ejection fraction (r = -0.65U, P = 0.01a, relative wall thickness r = 0.96P 0.01). 4. Multivariate linear regression analysis was used to control age, sex and cardiovascular risk factors. GDF-15 levels were positively correlated with left ventricular mass index (LVMI). Conclusion the high expression of GDF-15 in myocardial cells after acute myocardial infarction is involved in the process of left ventricular remodeling, and its level is significantly correlated with the degree of left ventricular remodeling.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R542.22

【参考文献】