丁苯酞注射液治疗老年急性脑梗死60例临床观察

发布时间：2018-06-16 08:34

本文选题：丁苯酞注射液 + 急性脑梗死　；参考：《宁夏医科大学学报》2013年08期

【摘要】：目的观察丁苯酞氯化钠注射液治疗老年急性脑梗死的临床疗效。方法收集2011年10月至2012年5月宁夏医科大学总医院收治的120例老年急性脑梗死患者,依据治疗方式分为两组,治疗组和对照组患者各60例,两组患者均给予基础治疗,如抗血小板聚集、调脂稳定斑块、改善循环等,确保基本治疗效果。治疗组在基础治疗基础上加用丁苯酞氯化钠注射液,疗程14d。记录治疗前后NIHSS、BI评分,观察临床疗效。并同时观察RBC和WBC计数,检测ALT、Cr、BUN;观察不良反应。结果两组患者治疗后NIHSS评分均较治疗前明显下降(P0.05),治疗后BI评分较治疗前明显升高(P0.05)。治疗组患者治疗后NIHSS评分低于对照组,BI评分高于对照组(P0.05)。治疗组总有效率明显高于对照组(P0.05)。两组治疗前后RBC计数、WBC计数、ALT、Cr、BUN均在正常范围,未出现明显的血象变化、肝肾功能损害等不良反应,且治疗过程中,患者无特殊不适。结论丁苯酞注射液治疗老年急性脑梗死可有效改善神经功能缺损,改善患者生活质量,具有确切的临床疗效。
[Abstract]:Objective to observe the clinical effect of butyphthalide sodium chloride injection in the treatment of senile acute cerebral infarction. Methods from October 2011 to May 2012, 120 elderly patients with acute cerebral infarction were divided into two groups: 60 patients in the treatment group and 60 in the control group. Such as anti-platelet aggregation, lipid stable plaque, improve circulation, to ensure the basic therapeutic effect. The treatment group was treated with butyphthalide sodium chloride injection on the basis of basic treatment for 14 days. NIHSSBI scores were recorded before and after treatment, and the clinical efficacy was observed. Meanwhile, RBC and WBC count were observed, alt Cr nBUNs were detected, and adverse reactions were observed. Results after treatment, NIHSS scores in both groups were significantly lower than those before treatment (P 0.05), and BI scores after treatment were significantly higher than those before treatment (P 0.05). The NIHSS score in the treatment group was lower than that in the control group (P 0.05). The total effective rate in the treatment group was significantly higher than that in the control group (P 0.05). Before and after treatment, the RBC count and WBC count were all in the normal range, and no obvious changes of blood and liver and kidney function were found in the two groups, and there was no special discomfort in the course of treatment. Conclusion butyphthalide injection in the treatment of senile acute cerebral infarction can effectively improve the neurological function defect and improve the quality of life of the patients.
【作者单位】：宁夏医科大学;宁夏医科大学总医院药剂科;宁夏医科大学总医院神经内科;
【基金】：石药集团恩必普药业有限公司资助项目(NBP-TST-1106)
【分类号】：R743.3

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