基于Lp-PLA2水平分析急性脑梗死与颈动脉粥样硬化斑块的关系

发布时间：2018-06-16 09:31

  本文选题：急性脑梗死 + 脂蛋白相关磷脂酶A　； 参考：《中国动脉硬化杂志》2017年09期

【摘要】：目的探讨急性脑梗死患者脂蛋白相关磷脂酶A2(Lp-PLA2)水平的变化特点及其与颈动脉粥样硬化斑块的关系。方法选取2013年6月至2014年10月来我院就诊确诊的82例急性脑梗死患者作为脑梗死组,并选取同期我院体检者82例作为对照组,彩色多普勒超声检测颈总动脉粥样硬化斑块,ELISA检测血清Lp-PLA2水平,Spearman相关分析急性脑梗死患者血清Lp-PLA2水平变化特点及其与梗死面积、颈动脉粥样硬化斑块Crouse积分之间的关系。结果脑梗死组Lp-PLA2、hs-CRP、TG、TC及LDLC的水平显著高于对照组,HDLC水平显著低于对照组(P0.05);颈动脉粥样硬化斑块Ⅰ级、Ⅱ级和Ⅲ级三组间Crouse积分、Lp-PLA2水平比较具有显著性差异,且随分级增加Lp-PLA2水平升高(P0.05);急性脑梗死患者Lp-PLA2水平随神经功能损伤程度增加而升高,Lp-PLA2水平与Crouse积分、梗死面积呈正相关(r=0.823和r=0.879,P0.05)。结论 Lp-PLA2水平与动脉粥样硬化性脑梗死有关,可反映患者颈动脉粥样硬化斑块及脑梗死面积情况,可作为脑梗死预测指标。
[Abstract]:Objective to investigate the changes of lipoprotein associated phospholipase A _ 2 (Lp-PLA _ 2) in patients with acute cerebral infarction and its relationship with carotid atherosclerotic plaque. Methods from June 2013 to October 2014, 82 patients with acute cerebral infarction were selected as cerebral infarction group, and 82 patients in our hospital were selected as control group. Detection of Common carotid Atherosclerotic plaque by Color Doppler Ultrasound Elisa Detection of Serum Lp-PLA2 level Spearman correlation Analysis of changes in Serum Lp-PLA2 levels and the relationship between Lp-PLA2 levels and infarct size and carotid Atherosclerotic plaque Crouse score in patients with Acute Cerebral Infarction (ACI). Results the levels of TGG TC and LDLC in cerebral infarction group were significantly higher than those in control group (P 0.05), and the levels of Crouse integral Lp-PLA2 in carotid atherosclerotic plaque grade 鈪，

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